51 documents found, page 1 of 6
Investigação clínica da iniciativa do investigador em Portugal: identificação d...
Ferreira, João Pedro; Leite-Moreira, Adelino; Da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenPortugal tem um problema crónico de subfinanciamento da investigação científica. Apesar do investimento nacional ter vindo a aumentar nos últimos anos, este ainda é manifestamente insuficiente. A Fundação para a Ciência e Tecnologia (FCT) financia anualmente projetos de investigação em todas as áreas científicas, limitando o valor máximo a €250 000 por projeto. Todavia, a área científica na qual a investigação ...
Persistence of IgG COVID-19 antibodies: a longitudinal analysis
Carvalho, Álvaro; Henriques, Ana Rita; Queirós, Paula; Rodrigues, Joana; Mendonça, Nuno; Rodrigues, Ana Maria; Canhao, Helena; Sousa, Germano deBackground and aim: The kinetics of antibody production in response to coronavirus disease 2019 (COVID-19) infection is not well-defined yet. This study aimed to evaluate the antibody responses to SARS-CoV-2 and its dynamics during 9-months in a cohort of patients infected during the first phase of the pandemic. As a secondary aim, it was intended to evaluate the factors associated with different concentrations...
Treatment-resistant depression and major depression with suicide risk — the cos...
Sousa, Rute Dinis; Gouveia, Miguel; Nunes da Silva, Catarina; Rodrigues, Ana Maria; Cardoso, Graça; Antunes, Ana Filipa; Canhao, HelenaIntroduction: Treatment-Resistant Depression (TRD) and Major Depression with Suicide Risk (MDSR) are types of depression with relevant effects on the health of the population and a potentially significant economic impact. This study estimates the burden of disease and the costs of illness attributed to Treatment-Resistant Depression and Major Depression with Suicide Risk in Portugal. Methods: The disease burden...
Obesity- attributable costs of absenteeism among working adults in Portugal
Destri, Kelli; Alves, Joana; Gregório, Maria João; Dias, Sara Simões; Henriques, Ana Rita; Mendonça, Nuno; Canhao, Helena; Rodrigues, Ana MariaBackground: Obesity leads to poor health outcomes and may adversely afect work productivity. This study, aimed to investigate the obesity- attributable costs of absenteeism among working adults in Portugal. Methods: The study population included individuals actively working at baseline from the Epidemiology of Chronic Diseases Cohort (EpiDoC), a large Portuguese population-based prospective study. Body mass ind...
SARS-CoV-2 antibody prevalence in the portuguese municipality of Vila Nova de G...
De Carvalho, Álvaro; Virgolino, Ana; Queirós, Paula; Henriques, Ana; Canhao, Helena; Rodrigues, Ana Maria; Barbosa, Veneranda; Rodrigues, JoanaIntroduction: Assessment of SARS-CoV-2 seroprevalence may detect the real spread of the virus because antibody data can provide a long-lasting measure of infection. Existing serological studies in Portugal have tested new serology methods, albeit with small sample sizes and a lack the focus on geographical regions with a high rate of infection cases. The aim of this study was to estimate the serological prevale...
Spotlight on latent tuberculosis infection screening for juvenile idiopathic ar...
Piotto, Daniela; Nicacio, Aline; Neto, Agna; Mourão, Ana Filipa; Oliveira Ramos, Filipa; Campanilho-Marques, Raquel; Guedes, Margarida; Cabral, MartaBackground: Rheumatic diseases are associated with an increase in overall risks of tuberculosis (TB). The aim of this study was to evaluate the frequency of TB and the frequency of latent TB infection (LTBI), in clinical practice, for juvenile idiopathic arthritis (JIA) patients from high and low risk of TB incidence endemic countries. Methods: This is an international, multicenter, cross-sectional, observation...
Sleep and awakening quality during COVID-19 confinement : complexity and releva...
Paiva, Teresa; Reis, Cátia; Feliciano, Amélia; Canas Simião, Hugo; Machado, Maria Augusta; Gaspar, Tania; Tomé, Gina; Branquinho, Cátia Sofia dos SantosObjective: The aim of this study was to evaluate sleep and awakening quality (SQ and AQ) during COVID-19 in a large and diversified population in order to identify significant associations and risks in terms of demography, health and health-related behaviors, sleep variables, mental health, and attitudes. Methods/results: Online surveys were used for data collection, received from 5479 individuals from the gene...
Atherosclerosis and bone loss in humans: results from deceased donors and from ...
Carmona-Fernandes, Diana; Barreira, Sofia; Leonardo, Natacha; Casimiro, Renata I.; Castro, Alice M.; Santos, Pedro Oliveira; Fernandes, António N.Background and Aims: Atherosclerosis and osteoporosis share common risk factors, as well as inflammatory mechanisms. Our aim was to understand how atherosclerotic lesions are related with disturbances in bone. Methods: Gene expression of pro-inflammatory and bone metabolism related proteins (IL-1β, IL-6, IL-17A, TNF, RANKL, OPG, COL1, CTSK, OCL, TRAP, CBFA1, DKK1, SOST, ADIPOQ, and ADIPOR1) were analyzed in art...
NFKB2 polymorphisms associate with the risk of developing rheumatoid arthritis ...
Manuel Sánchez-Maldonado, Jose; Martínez-Bueno, Manuel; Canhao, Helena; ter Horst, Rob; Muñoz-Peña, Sonia; Moñiz-Díez, Ana; Rodríguez-Ramos, AnaThis study sought to evaluate the association of 28 single nucleotide polymorphisms (SNPs) within NFKB and inflammasome pathway genes with the risk of rheumatoid arthritis (RA) and response to TNF inhibitors (TNFi). We conducted a case-control study in a European population of 1194 RA patients and 1328 healthy controls. The association of potentially interesting markers was validated with data from the DANBIO (...
Reuma.pt/vasculitis : the Portuguese vasculitis registry
Ponte, Cristina; Khmelinskii, Nikita; Teixeira, Vítor; Luz, Karine; Peixoto, Daniela; Rodrigues, Marília; Luís, Mariana; Teixeira, Lídia; Sousa, SandraBackground: The vasculitides are a group of rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. The Rheumatic Diseases Portuguese Register, Reuma.pt, is a web-based electronic clinical record, created in 2008, which currently includes specific modules for 12 diseases and > 20,000 patients registered from 79 rheumatology centres. On Oct...