32 documents found, page 1 of 4
Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, A.; Bicker, Joana; Sánchez-López, Elena; Paz, Cristian; Ureña, Jesús; Verdaguer, EsterLicochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza species has shown promise in treating various diseases such as cancer, obesity, and skin diseases due to its active compounds, the investigation of Licochalcone A's effects on the central nervous system and its potential application in Alz...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Physicochemical and biopharmaceutical aspects influencing skin permeation and r...
Souto, Eliana B.; Fangueiro, Joana F.; Fernandes, Ana R.; Cano, Amanda; Sanchez-Lopez, Elena; Garcia, Maria L.; Severino, Patrícia; Paganelli, Maria O.The skin is a complex and multifunctional organ, in which the static versus dynamic balance is responsible for its constant adaptation to variations in the external environment that is continuously exposed. One of the most important functions of the skin is its ability to act as a protective barrier, against the entry of foreign substances and against the excessive loss of endogenous material. Human skin impose...
Photoprotection and skin irritation effect of hydrogels containing hydroalcohol...
Batista, Cinthia M.; Queiroz, Luma A. de; Alves, Ângela V. F.; Reis, Elisiane C. A.; Santos, Fagne A.; Castro, Tailaine N.; Lima, Bruno S.The use of natural products in sunscreen formulations as a prophylactic measure against skin cancer is receiving special attention attributed to the photoprotective and antioxidant properties of their chemical components. In this work, we describe the development of topical hydrogel formulations containing hydroalcoholic extract of red propolis (HERP), and the evaluation of the dermal sensitizing effect of the ...
Biodegradable nanoparticles for the treatment of epilepsy: from current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Liposomal formulations of oxybutynin and resiniferatoxin for the treatment of u...
Cirino, Lorena M. D.; Vergne, Daviane M. C.; Novais, Gabrielle B.; Cano, Amanda; Padilha, Francine F.; Severino, PatríciaThe use of liposomes for drug release has demonstrated to be a promising therapeutic platform for biomedical applications. In this study, intravesical administration of OXI (1.5 mM) and RTX (100 nM) was used to compare histological changes caused in Wistar female rats by the drugs both unloaded and loaded in liposomes. After instillation of formulations by intravesical catheter, bladders were removed and histol...
Encapsulation of Active Pharmaceutical Ingredients in Lipid Micro/Nanoparticles...
Favaro-Trindade, Carmen S.; Matos Junior, Fernando E. de; Okuro, Paula K.; Dias-Ferreira, João; Cano, Amanda; Severino, Patricia; Zielińska, AleksandraNanoencapsulation via spray cooling (also known as spray chilling and spray congealing) has been used with the aim to improve the functionality, solubility, and protection of drugs; as well as to reduce hygroscopicity; to modify taste and odor to enable oral administration; and many times to achieve a controlled release profile. It is a relatively simple technology, it does not require the use of low-cost solve...
Elastic and Ultradeformable Liposomes for Transdermal Delivery of Active Pharma...
Souto, Eliana; Macedo, Ana S; Dias-Ferreira, João; Cano, Amanda; Zielińska, Aleksandra; Matos, Carla M.Administration of active pharmaceutical ingredients (APIs) through the skin, by means of topical drug delivery systems, is an advanced therapeutic approach. As the skin is the largest organ of the human body, primarily acting as a natural protective barrier against permeation of xenobiotics, specific strategies to overcome this barrier are needed. Liposomes are nanometric-sized delivery systems composed of phos...