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The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antag...

Agache, I; Adcock, IM; Akdis, CA; Akdis, M; Bentabol-Ramos, G; van den Berge, M; Boccabella, C; Canonica, WG; Caruso, C; Couto, M; Davila, I

As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in asthma patients who remained poorly controlled despite treatment with ...


Next-Generation Allergic Rhinitis and Its Impact on Asthma (ARIA) Guidelines fo...

Bousquet, J; Schünemann, HJ; Togias, A; Bachert, C; Erhola, M; Hellings, PW; Klimek, L; Pfaar, O; Wallace, D; Ansotegui, I; Agache, I; Walker, S

The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical practice, especially because randomized controlle...


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