6 documents found, page 1 of 1
Analysis of the biological effect of Carica papaya leaf extracts on the viabili...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, AnitaBackground – Sickle cell disease (SCD) is a genetic blood disorder caused by mutations in the β-globin gene that affects the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of fetal hemoglobin (HbF) through compounds such as hydroxyurea (HU), is one of the currently available treatments, however, their safety concerns and expen...
Effects of Quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal ...
Effects of quercetin in transcriptional and post-transcriptional regulation of ...
Canteiro, Beatriz; Mendes, Maria; Jacques, Filipa; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle Cell anemia (SCA) is a hereditary hemoglobinopathy with the formation of hemoglobin S, associated with severe health outcomes. Currently, induction of fetal hemoglobin (HbF) is one of the most promising therapeutic strategies. Here we aimed to assess the potential of the natural compound Quercetin, in transcriptional expression of globin and HbF regulatory/silencing genes. In this study, the K562 cell li...
Análise do efeito biológico de extratos de folhas de Carica papaya na viabilida...
Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Introdução – A anemia falciforme é uma doença monogénica causada por mutações no gene da β-globina que afeta a estrutura da hemoglobina, sendo associada a diversas complicações clínicas com elevadas taxas de morbilidade e mortalidade. A reativação farmacológica da hemoglobina fetal (HbF) por compostos como a hidroxiureia (HU) é um dos tratamentos atualmente disponíveis; contudo, o seu perfil de segurança e o el...
Effects of methanolic and aqueous Carica Papaya leaf extracts in transcriptiona...
Jacques, Filipa; Canteiro, Beatriz; Mendes, Maria; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, MiguelSickle cell disease (SCD) is a genetic blood disorder caused by mutations in β-globin gene that affect the shape and transport of red blood cells in blood vessels, leading to various clinical complications. The pharmacological reactivation of Fetal Hemoglobin (HbF) through compounds such as Hydroxyurea (HU), is one of the available treatments, however, their safety concerns and expensive cost in low- and middle...
Effects of Carica papaya leaf extracts in transcriptional regulation of fetal h...
Mendes, M.; Canteiro, Beatriz; Delgadinho, Mariana; Oliveira, Ketlyn; Ginete, Catarina; Gomes, Mário; Ribeiro, Edna; Brito, Miguel; Gomes, Anita Q.Purpose: Sickle cell disease (SCD) is one of the most common human genetic disorders, which is caused by a single point mutation (Glu6Val) on the HBB gene. Currently, one of the treatments for this global health problem involves the induction of fetal hemoglobin (HbF). There are some drugs on the market that pharmacologically induce HbF, namely Hydroxyurea (HU), however, their safety concerns and the expensive ...