8 documents found, page 1 of 1
A case of success: complete response to Radium-223 in metastatic castration-res...
Soares De Pinho, Inês; Esperança Martins, Miguel; Machado, Bárbara; Dâmaso, Sara; Brás, Raquel; Cantinho, Guilhermina; Fernandes, Isabel; Costa, LuisRadium-223 dichloride (Ra223) is the first targeted alpha agent approved for treating metastatic castration-resistant prostate cancer (mCRPC) with bone-exclusive disease. A benefit in overall survival and time to the first symptomatic skeletal-related event was shown in the Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial. However, this trial did not describe a bone scan response to Ra223, an...
The sensitivity of DPD scintigraphy to detect transthyretin cardiac amyloidosis...
Coutinho, Maria Conceição Azevedo; Cortez-Dias, Nuno; Cantinho, Guilhermina; Gonçalves, Susana; Menezes, Miguel Nobre; Guimarães, TatianaBackground: There is a growing need for a non-invasive test to detect cardiac involvement in patients with transthyretin-related hereditary amyloidosis (ATTR) caused by V30M mutation. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scintigraphy is a promising method, but its accuracy in this particular mutation remains unknown. Methods: A cohort of 179 patients: 92 with early-onset disease (EoD, sympto...
Progression of myocardial sympathetic denervation assessed by 123I-MIBG imaging...
Coutinho, Maria da Conceição Azevedo; Dias, Nuno Cortez; Cantinho, Guilhermina; Conceição, Isabel; Guimarães, Tatiana; Silva, Gustavo Lima daIntroduction: Familial amyloid polyneuropathy (FAP) is a rare disease caused by systemic deposition of amyloidogenic variants of the transthyretin (TTR) protein. The TTR-V30M mutation is caused by the substitution of valine by methionine at position 30 and mainly affects the peripheral and autonomic nervous systems. Cardiovascular manifestations are common and are due to autonomic denervation and to amyloid dep...
Influence of attenuation correction in the MPI image reconstructed by the ‘Evol...
Ribeiro, Daniela; Vilaça, Joana; Nunes, Cristiano; Freire, Luís; Pinheiro, Marco; Cantinho, Guilhermina; Carolino, Elisabete; Sousa, EvaThe acquisition of a Myocardial Perfusion image (MPI) is of great importance for the diagnosis of the coronary artery disease, since it allows to evaluate which areas of the heart aren’t being properly perfused, in rest and stress situations. This exam is greatly influenced by photon attenuation which creates image artifacts and affects quantification. The acquisition of a Computerized Tomography (CT) image mak...
Estimation of the collective ionizing dose in the Portuguese population for the...
Costa, F.; Teles, P.; Nogueira, A.; Barreto, A.; Santos, A.I.; Carvalho, A.; Martins, B.; Oliveira, C.; Gaspar, C.; Barros, C.; Neves, D.; Costa, D.Objectives: In 2009-2010 a Portuguese consortium was created to implement the methodologies proposed by the Dose Datamed II (DDM2) project, aiming to collect data from diagnostic X-ray and nuclear medicine (NM) procedures, in order to determine the most frequently prescribed exams and the associated ionizing radiation doses for the Portuguese population. The current study is the continuation of this work, altho...
Reduced myocardial 123-Iodine metaiodobenzylguanidine uptake : a prognostic mar...
Coutinho, Maria C. Azevedo; Dias, Nuno Cortez; Cantinho, Guilhermina; Conceição, Isabel; Oliveira, António; Sá, Armando Bordalo e; Gonçalves, SusanaBackground: Transthyretin familial amyloid polyneuropathy is a hereditary form of amyloidosis characterized by sensorimotor and autonomic neuropathy, cardiac conduction defects, and infiltrative cardiomyopathy. Previous studies have suggested that myocardial sympathetic denervation assessed by 123-iodine metaiodobenzylguanidine (MIBG) imaging occurs early in disease progression. However, its prognostic signific...
Reflex sympathetic dystrophy.
Oliveira, Marta; Manuela, Manuela; Cantinho, GuilherminaReflex Sympathetic Dystrophy is rare in pediatrics. It is a complex regional pain syndrome, of unknown etiology, usually post-traumatic, characterized by dysfunctions of the musculoskeletal, vascular and skin systems: severe persistent pain of a limb, sensory and vascular alterations, associated disability and psychosocial dysfunction. The diagnosis is based in high clinical suspection. In children and adolesce...
Cost-effectiveness of samarium-153-EDTMP for the treatment of pain due to multi...
Macedo, Ana; Araújo, António; Melo, Fernando Carvalho; Nunes, Garção; Cantinho, Guilhermina; Amorin, InêzProstate cancer is a significant cause of morbidity and mortality. In Portugal alone, according to a study published in 2003, the rate of new prostate cancer cases were 53 per 100,000 men (in 2000), with an age-standardized mortality rate of about 28 per 100,000 (in 1995). Multiple bone metastases are one of the major complications of advanced prostate cancer. Samarium-EDTMP showed to be a safe and effective al...