10 documents found, page 1 of 1
Anti-Inflammatory Meroterpenoids of Cordia glazioviana (Boraginaceae)
Silva,Ana Karine O.; Pinto,Francisco C. L.; Canuto,Kirley M.; Braz-Filho,Raimundo; Silva,Rose Anny C.; Santos,Flávia A.; Monteiro,Norberto K. V.The phytochemical reinvestigation from the heartwood of the extracts of Cordia glazioviana led to the isolation of four still undescribed hydroquinones derivatives designated as cordiaquinol D (1), cordiaquinol E (2), (10R)-10,11-dihydrofuran-1,4-dihydroxy-globiferin (3) and 2-[(1’E,6’E)-3’,8’- dihydroxy-3’,7’-dimethylocta-1’,6’-dienyl]-benzene-1,4-diol (4), along with the naphthoquinone 6-[(2’R)-2’-hydroxy-3’,...
Integrated UPLC-HRMS, Chemometric Tools, and Metabolomic Analysis of Forage Pal...
Matos,Thiago Kelvin B.; Guedes,Jhonyson A. C.; Alves Filho,Elenilson G.; Luz,Licia R.; Lopes,Gisele Simone; Nascimento,Ronaldo F. do; Sousa,João A. deMetabolomics, together with analytical methods and chemometric tools, point to new paths for selecting species that are resistant to pests and diseases. In this work, the forage palm species' metabolomic profile was investigated, and the relation between the chemical composition and resistance to Dactylopius opuntiae (carmine cochineal). The study was performed in cladodes of different non-susceptible cultivars...
Development and Validation of a UPLC-ESI-MS Method for Quantitation of the Anti...
Paiva,José R. de; Souza,Ana S. Q.; Pereira,Rita de C. A.; Ribeiro,Paulo R. V.; Zocolo,Guilherme J.; Brito,Edy S. de; Pessoa,Otília D. L.Our study aimed at the development of a method based on ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-ESI-MS) using selected ion monitoring for the simultaneous quantitation of the alkaloids galantamine, pseudolycorine, sanguinine and narciclasine in Amaryllidaceae species (Hippeastrum elegans, Habranthus cf. irwinianus, Hymenocallis littoralis and Griffinia nocturna). The alkaloids...
GC-MS-Based Metabolomic Profiles Combined with Chemometric Tools and Cytotoxic ...
Guedes,Jhonyson A. C.; Alves Filho,Elenilson G.; Silva,Maria F. S.; Rodrigues,Tigressa H. S.; Ramires,Christiane M. C.; Lima,Maria A. C.Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy ...
Metabolomics-Based Discovery of Biomarkers with Cytotoxic Potential in Extracts...
Castro,Caio B.; Luz,Licia R.; Guedes,Jhonyson A. C.; Porto,Diogo D.; Silva,Maria Francilene S.; Silva,Gisele S.; Ribeiro,Paulo R. V.; Canuto,Kirley M.Myracrodruon urundeuva (“aroeira-do-sertão”) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid...
Withanolides from Leaves of Nicandra physalodes
Carrero,Diego A. S.; Batista,Pedro H. J.; Souza,Luciana G. S.; Pinto,Francisco C. L.; Vasconcelos,Mayron A. de; Teixeira,Edson H.; Canuto,Kirley M.Five new withanolides, designated as 15-oxo-nicaphysalin B, 6β,7α-dihydroxynicandrenone 10, 24α,25β-dihydroxy-nicandrenone-2 and a mixture of the epimers 17-(1α/1β-methylpropanone)-nicandrenone, in addition to six known others, were isolated from the leaf acetone extract from Nicandra physalodes. The complete structures of the five new withanolides, particularly their relative stereochemistries, were establishe...
Brazoides A-D, New Alkaloids from Justicia gendarussa Burm. F. Species
Souza,Luciana G. S.; Almeida,Macia C. S.; Lemos,Telma L. G.; Ribeiro,Paulo R. V.; Canuto,Kirley M.; Braz-Filho,Raimundo; Cistia,Catarina N. DelFour new alkaloids, Brazoides A-D, together with three known compounds squalene, β-sitosterol and lupeol, were isolated from leaves of Justicia gendarussa. These structures were established by spectrometric techniques, mainly high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR), including comparative analysis with literature values. Structural determ...
Amburanins A and B from Amburana cearensis: daphnodorin-type biflavonoids that ...
Canuto,Kirley M.; Leal,Luzia K. A. M.; Lopes,Amanda A.; Coleman,Christina M.; Ferreira,Daneel; Silveira,Edilberto R.Two new biflavonoids 3,5,7,4'-tetrahydroxyflavanone-(2→O→4':3→3')-2',4',6',4-tetrahydroxydihydrochalcone (1) and 3,5,7,4'-tetrahydroxyflavanone-(2→O→7:3→8)-3,4',5,7-tetrahydroxyflavone (2), named as amburanin A and amburanin B, respectively, were isolated from the trunk bark of Amburana cearensis, and their structures elucidated on the basis of spectroscopic analysis and by comparison with literature data. The ...
Influence of process conditions on the physicochemical characteristics of cumar...
Araruna,Sandra M.; Silva,Aline H.; Canuto,Kirley M.; Silveira,Edilberto R.; Leal,Luzia Kalyne A. M.The aim of the work was to study the spray-drying of ethanolic extract from Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in order to obtain powders with better pharmacological and technological properties for herbal medicine. A 2³ fractional factorial statistical design was used to find adequate spray-drying operating conditions (inlet air temperature; feed flow rate and air flow rate) to produce A. cearens...
Leaf essential oils of four Piper species from the State of Ceará - Northeast o...
Cysne,Juliana B.; Canuto,Kirley M.; Pessoa,Otília Deusdênia L.; Nunes,Edson P.; Silveira,Edilberto R.The essential oils, obtained by hydrodistillation, from leaf samples of four Piper species (P. arboreum, P. crassinervium, P. dilatatum and P. tuberculatum), harvested at the State of Ceará, were analyzed by GC-MS. The oil yields ranged from 0.03 to 0.11% (w/w), on fresh weight basis. The oils were characterized by mono- and sesquiterpenes, except the oil of P. arboreum to which only sesquiterpenes were identif...