7 documents found, page 1 of 1
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, TPhytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, ne...
Vanden Eynde, JJ; Mangoni, AA; Rautio, J; Leprince, J; Azuma, YT; García-Sosa, AT; Hulme, C; Jampilek, J; Karaman, R; Li, W; Gomes, PAC
Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, Ne...
Mangoni, AA; Eynde, JJV; Jampilek, J; Hadjipavlou-Litina, D; Liu, H; Reynisson, J; Sousa, ME; Gomes, PAC; Prokai-Tatrai, K; Tuccinardi, T; Sabatier, JM
Cucurbits plants: A key emphasis to its pharmacological potential
Salehi, B; Capanoglu, E; Adrar, N; Catalkaya, G; Shaheen, S; Jaffer, M; Giri, L; Suyal, R; Jugran, A; Calina, D; Docea, A; Kamiloglu, S; Kregiel, DCucurbita genus has received a renowned interest in the last years. This plant species, native to the Americas, has served worldwide folk medicine for treating gastrointestinal diseases and intestinal parasites, among other clinical conditions. These pharmacological effects have been increasingly correlated with their nutritional and phytochemical composition. Among those chemical constituents, carotenoids, toc...
Predictors of Nasal Obstruction: Quantification and Assessment Using Multiple G...
Camacho, M; Zaghi, S; Certal, V; Abdullatif, J; Modi, R; Sridhara, S; Tolisano, AM; Chang, ET; Cable, BB; Capasso, RObjective. To evaluate the association between nasal obstruction and (1) demographic factors, (2) medical history, (3) physical tests, and (4) nasal exam findings. Study Design. CASE SERIES: Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1 ± 17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE) score of 32.0 ± 24.1) were included. Demographic...
Awake examination versus DISE for surgical decision making in patients with OSA...
Certal, VF; Pratas, R; Guimarães, L; Lugo, R; Tsou, Y; Camacho, M; Capasso, ROBJECTIVE: Traditionally, upper airway examination is performed while the patient is awake. However, in the past two decades, drug-induced sleep endoscopy (DISE) has been used as a method of tridimensional evaluation of the upper airway during pharmacologically induced sleep. This study aimed to systematically review the evidence regarding the usefulness of DISE compared with that of traditional awake examinati...
Myofunctional Therapy to Treat Obstructive Sleep Apnea: A Systematic Review and...
Camacho, M; Certal, V; Abdullatif, J; Zaghi, S; Ruoff, CM; Capasso, R; Kushida, CAOBJECTIVE: To systematically review the literature for articles evaluating myofunctional therapy (MT) as treatment for obstructive sleep apnea (OSA) in children and adults and to perform a meta-analysis on the polysomnographic, snoring, and sleepiness data. DATA SOURCES: Web of Science, Scopus, MEDLINE, and The Cochrane Library. REVIEW METHODS: The searches were performed through June 18, 2014. The Preferred Re...