28 documents found, page 1 of 3
Bioactive Properties and Phenolic Composition of Wood-Aged Beers: Influence of ...
Machado, JC; Nicola, PDM; Viegas, Olga; Santos, MC; Faria, MA; Ferreira, IMPLVOAgeing beer in contact with wood is a common technological procedure that has been used for centuries to improve colour, structure, and certain flavours. Herein, the impact of the addition of French and American oak wood to two beer styles, pale and dark, on beer phenolic composition (total phenolics, total flavonoids, and HPLC-DAD) and bioactivity (FRAP, DPPH, anti-inflammatory activity in RAW 264.7, and antip...
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
Liquid biopsy for disease monitoring in non-small cell lung cancer: The link be...
Fernandes, G; Sousa, C; Reis, J; Martins, N; Moura, CS; Guimarães, S; Justino, A; Pina, MJ; Magalhães, A; Queiroga, H; Marques, JA; Machado, JCIntroduction: Cell-free DNA (cfDNA) analysis offers a non-invasive method to identify sensitising and resistance mutations in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Next-generation sequencing (NGS) of circulating free DNA (cfDNA) is a valuable tool for mutations detection and disease' s clonal monitoring. Material and methods: An amplicon-based targeted gene NGS panel was used to analyse 101 plas...
The value of cell-free circulating tumour DNA profiling in advanced non-small c...
Fernandes, G; Martins, N; Machado, JC; Costa, JL; Hespanhol, VLiquid biopsy (LB) has boosted a remarkable change in the management of cancer patients by contributing to tumour genomic profiling. Plasma circulating cell-free tumour DNA (ctDNA) is the most widely searched tumour-related element for clinical application. Specifically, for patients with lung cancer, LB has revealed valuable to detect the diversity of targetable genomic alterations and to detect and monitor th...
The Porto European Cancer Research Summit 2021
Ringborg, U; Berns, A; Celis, JE; Heitor, M; Tabernero, J; Schüz, J; Baumann, M; Henrique, R; Aapro, M; Basu, P; Beets-Tan, R; Besse, B; Cardoso, FKey stakeholders from the cancer research continuum met in May 2021 at the European Cancer Research Summit in Porto to discuss priorities and specific action points required for the successful implementation of the European Cancer Mission and Europe's Beating Cancer Plan (EBCP). Speakers presented a unified view about the need to establish high-quality, networked infrastructures to decrease cancer incidence, in...
The Dysfunctional Immune System in Common Variable Immunodeficiency Increases t...
Gullo, I; Costa, C; Silva, SL; Ferreira, C; Motta, A; Silva, SP; Ferreira, RD; Rosmaninho, P; Faria, E; Costa, JTd; Câmara, R; Gonçalves, GGastric carcinoma (GC) represents the most common cause of death in patients with common variable immunodeficiency (CVID). However, a limited number of cases have been characterised so far. In this study, we analysed the clinical features, bacterial/viral infections, detailed morphology and immune microenvironment of nine CVID patients with GC. The study of the immune microenvironment included automated digital...
Genetic Variants of the MGAT5 Gene Are Functionally Implicated in the Modulatio...
Pereira, MS; Durães, C; Catarino, TA; Costa, JL; Cleynen, I; Novokmet, M; Krištic, J; Štambuk, J; Conceição-Neto, N; Machado, JC; Marcos-Pinto, ROBJECTIVES: The impact of genetic variants (single nucleotide polymorphisms [SNPs]) in the clinical heterogeneity of ulcerative colitis (UC) remains unclear. We showed that patients with UC exhibit a deficiency in MGAT5 glycogene transcription in intestinal T cells associated with a hyperimmune response. Herein, we evaluated whether MGAT5 SNPs might functionally impact on T cells glycosylation and plasma IgG gl...
The influence of the genetic and immunologic context in the development of colo...
Garcia, D; Spaans, L; Miranda, S; Gonçalves, G; Reis, J; Costa, JL; Durães, C; Carneiro, F; Machado, JCIntroduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...
Longitudinal assessment of the effectiveness of a tobacco prevention programme ...
Sousa, I; Rocha, V; Samorinha, C; Machado, JC; Antunes, H; Precioso, JImplementing effective prevention programmes is critical to prevent tobacco use. Objectives. This study aims to assess the long-term effectiveness of the "SmokeOut-I" programme in the smoking prevention of school-aged adolescents, by gender. Methodology.A quasi-experimental study was conducted including a pre-test and a post-test, as well as an experimental group (N = 163) and a control group (N = 148) of adole...
Quality of life in elderly Portuguese war veterans with post-traumatic stress s...
Pereira, MG; Machado, JC; Pereira, M; Lopes, C; Pedras, SBACKGROUND: Studies show that post-traumatic stress symptoms among Portuguese veterans who participated in Colonial War (1961-75) are high, even though 43 years have gone by since the end of the war. AIMS: This study analyzed the role of family type, personality traits, and social support as predictors of post-traumatic stress symptoms and quality of life in war veterans, and whether satisfaction with social su...