3 documents found, page 1 of 1
NORAD-regulated signaling pathways in breast cancer progression
Capela, Ana Maria; Tavares-Marcos, Carlota; Estima-Arede, Hugo F.; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deLong non-coding RNA activated by DNA damage (NORAD) has recently been associated with pathologic mechanisms underlying cancer progression. Due to NORAD's extended range of interacting partners, there has been contradictory data on its oncogenic or tumor suppressor roles in BC. This review will summarize the function of NORAD in different BC subtypes and how NORAD impacts crucial signaling pathways in this patho...
Expression of NORAD correlates with breast cancer aggressiveness and protects b...
Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla PereiraThe recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosomal instability and aneuploidy, which contributes to the accumulation of genetic abnormalities and tumorigenesis. NO...
Non-coding antisense transcripts: fine regulation of gene expression in cancer
Santos, Francisco; Capela, Ana Maria; Mateus, Francisca; Nóbrega-Pereira, Sandrina; Jesus, Bruno Bernardes deNatural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another ...