5 documents found, page 1 of 1
Polypharmacological strategies for infectious bacteria
Leita, MM; Gonçalves, ASC; Borges, F; Simoes, M; Anabela BorgesPolypharmacological approaches have significant potential for the treatment of various complex diseases, including infectious bacteria-related diseases. Actually, multitargeting agents can achieve better therapeutic effects and overcome the drawbacks of monotherapy. Although multidrug multitarget strategies have demonstrated the ability to inactivate infectious bacteria, several challenges have been pointed out...
Antibacterial effects of novel quaternary ammonium and phosphonium salts agains...
Nunes, B; Cagide, F; Anabela Borges; Borges, F; Simoes, MAim This study investigates the mechanisms of action of a promising series of previously synthesized quaternary ammonium (QASs) and phosphonium (QPSs) salts, which have shown potent activity against Staphylococcus aureus, including methicillin-resistant strains (MRSA).Methods and results The effects of QASs and QPSs on S. aureus surface charge, total surface hydrophobicity, intracellular potassium release, memb...
Phytochemicals and quaternary phosphonium ionic liquids: Connecting the dots to...
Chavarria, D; Anabela Borges; Benfeito, S; Sequeira, L; Ribeiro, M; Oliveira, C; Borges, F; Simões, M; Cagide, F; Simões MIntroduction: The infections by multidrug-resistant bacteria are a growing threat to human health, and the efficacy of the available antibiotics is gradually decreasing. As such, new antibiotic classes are urgently needed. Objectives: This study aims to evaluate the antimicrobial activity, safety and mechanism of action of phytochemical-based triphenylphosphonium (TPP') conjugates. Methods: A library of phytoch...
The impact of early protein intake and nutritional status in critically ill pat...
Martinho-Gomes, S; Carvalho, C; Borges, F; Ramos, A
Verrucous herpes zoster in AIDS patients.
Agusto, V; Franca, I; Mansinho, K; Araújo, C; Borges, F; Champalimaud, J L; Poiares-Baptista, A; Martins, C; Ricardo, J LThe authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with AIDS. Hyperkeratotic characteristics, acyclovir resistance and sensitivity to foscarnet of cutaneous lesions are the most important features of this example. From the casuistics of the department, the authors describe two similar cases and review the medical literature with emphasis on etiopathogenic, diagnostic an...