2 documents found, page 1 of 1
Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) na...
Zhan, Yuan; Gonçalves, Mara; Yi, Panpan; Capelo, Débora; Zhang, Yuhong; Rodrigues, João; Liu, Changsheng; Tomás, Helena; Li, Yulin; He, PeixinThe clinical application of doxorubicin (DOX), like other anticancer drugs, is limited by insufficient cellular uptake and the numerous drug resistance mechanisms existing in cells. The development of smart nanomaterials capable of carrying the drugs into the cells and of releasing them under the control of the microenvironment is an interesting approach that may increase the success of the anticancer drugs curre...
Dendrimer-assisted formation of fluorescent nanogels for drug delivery and intr...
Gonçalves, Mara; Maciel, Dina; Capelo, Débora; Xiao, Shili; Sun, Wenjie; Shi, Xiangyang; Rodrigues, João; Tomás, Helena; Li, YulinAlthough, in general, nanogels present a good biocompatibility and are able to mimic biological tissues, their unstability and uncontrollable release properties still limit their biomedical applications. In this study, a simple approach was used to develop dual-cross-linked dendrimer/alginate nanogels (AG/G5), using CaCl2 as cross-linker and amine-terminated generation 5 dendrimer (G5) as a cocrosslinker, throu...