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Inhibition of P-glycoprotein activity by cucurbitane-type triterpenes and their...
Ramalhete, Cátia; Duarte, N; Capucha, V; Molnár, J; Mulhovo, S; Rosário, V; Ferreira, MJUThe overexpression of P- glycoprotein (P-gp) is one of the mechanisms of multidrug resistance (MDR), responsible for the failure of cancer treatment. One strategy to restore the effectiveness of the anti-cancer drugs is to co-administer compounds that are not toxic themselves, but inhibit these efflux pumps. These compounds have been called MDR inhibitors, MDR modulators, MDR reversal agents or chemosensitizers...
Date: 2012
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Origin: Repositório Científico Atlântica
Inhibition of P-glycoprotein activity by curcubitane-type triterpenes and their...
Ramalhete, C.; Duarte, N.; Capucha, V; Molnar, J.; Mulhovo, S.; Rosario, V; Ferreira, M. J. U.
Date: 2009
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Origin: Repositório da Universidade de Lisboa