74 documents found, page 1 of 8
TRATAMENTO DO MELANOMA OCULAR COM PDT EM MODELO HETEROTÓPICO
Guerra Guimarães, Tarcísio; Menezes Cardoso, Karla; Caramelo, Francisco; Pereira, Nélson; Pineiro, Marta; Pinho e Melo, Teresa; Alexandre, NunoIntrodução: O melanoma ocular tem motivado vastas pesquisas tanto na medicina humana quanto veterinária devido ao baixo sucesso dos tratamentos conservadores1. A Terapia Fotodinâmica (PDT) oferece uma abordagem mais conservadora, que se destaca pela sua seletividade, que é influenciada pela penetração do fotossensibilizador nas células tumorais e irradiação direcionada da área afetada1,2. A Clorina 1 (Derivado ...
COMPARAÇÃO DOS TONÔMETROS TONOLAB®, TONOVET PLUS® E TONO-PEN AVIA VET® NA AFERI...
Guerra Guimarães, Tarcísio; Menezes Cardoso, Karla; Caramelo, Francisco; Carvalho, Luis; Monteiro, João; Marto, Carlos Miguel; Ambrósio, António F.Introdução: A tonometria é fundamental para o diagnóstico e acompanhamento de doenças oftalmológicas. Assim, equipamentos que medem a pressão intraocular (PIO) de maneira precisa e reprodutível tornaram-se importantes para identificar hipo ou hipertensão intraocular, monitorar a progressão de doenças e avaliar a eficácia de terapeuticas1,2,3. Os tonômetros mais comuns para uso clínico em animais têm sido os ton...
Comparação entre ultrassonografia e exame histológico para identificação de mel...
Guerra Guimarães, Tarcísio; Menezes Cardoso, Karla; Cardoso, Nuno; Gama, João; Caramelo, Francisco; Pereira, Nelson; Pineiro, MartaIntrodução: A ecografia ocular é um exame essencial no diagnóstico de melanomas intraoculares, sendo uma técnica complementar, rápida e segura, que pode ser realizada em ambulatório1. Ferramentas diagnósticas não invasivas é indispensável para mapear com precisão a extensão do melanoma, especialmente diante de opacificação dos meios transparentes, orientando a decisão sobre tratamentos conservadores ou exérese ...
Influence of Aldehyde Dehydrogenase Inhibition on Stemness of Endometrial Cance...
Serambeque, Beatriz; Mestre, Catarina; Barros, Gabriela; Marques Teixo, Ricardo Jorge; Marto, Carlos Miguel; Gonçalves, Ana CristinaPublisher Copyright: © 2024 by the authors.; Endometrial cancer is one of the most common gynaecological malignancies. Although often diagnosed at an early stage, there is a subset of patients with recurrent and metastatic disease for whom current treatments are not effective. Cancer stem cells (CSCs) play a pivotal role in triggering tumorigenesis, disease progression, recurrence, and metastasis, as high aldeh...
Three-Dimensional Pulp Volume Analysis in Lip and Palate Cleft Population
Francisco, Inês; Travassos, Raquel; Marques, Filipa; Ribeiro, Madalena Prata; Rodrigues, Mariana; Quaresma, Patrícia; Caramelo, FranciscoAim: Cleft lip and palate (CLP) patients have a greater predisposition to tooth malformation, which could affect pulp volume. The aim of this study is to evaluate the dental pulp volume of central incisors in 3D images between individuals with and without CLP. Materials and Methods: This retrospective case-control study is single-centered and was recruited between January 2016 and October 2022. Ninety-four pati...
Relapse after Orthodontic-Surgical Treatment: A Retrospective Longitudinal Study
Matos, João; Travassos, Raquel; Caramelo, Francisco; Ribeiro, Madalena Prata; Marques, Filipa; Marto, Carlos Miguel; Paula, Anabela BaptistaLong-term stability is a crucial point in order to keep the patient’s aesthetic and functional balance. The aim of this study was to evaluate dental and skeletal relapse in patients who underwent orthodontic-surgical treatment. This retrospective study included 25 patients who corrected their dentofacial deformity through orthodontics and orthognathic surgery. The dental casts and lateral cephalograms were eval...
Bone Mineral Density through DEXA and CBCT: A Systematic Review with Meta-Analysis
Francisco, Inês; Nunes, Catarina; Pereira, Flávia; Travassos, Raquel; Ribeiro, Madalena Prata; Marques, Filipa; McEvoy, Mariana; Santos, MarianaDual-energy X-ray absorptiometry is used to determine bone density in several pathologies, namely osteoporosis and fracture risk in post-menopausal women. The aim of this study was to identify, appraise and synthesize all available evidence about the correlation between Dual Energy X-ray Absorptiometry (DEXA) and Cone Beam Computed Tomography (CBCT) techniques through a systematic review. A systematic literatur...
Realistic Facial Three-Dimensional Reconstruction from CT Images and 2D Photogr...
Monteiro, Miguel; Vale, Francisco; Ferreira, Nuno C.; Marques, Filipa; Ribeiro, Madalena Prata; Santos, Mariana; Oliveira, Catarina; McEvoy, MarianaOrthognathic surgery is a procedure used to correct intermaxillary discrepancies, thus promoting significant improvements in chewing and breathing. During the surgical planning stage, orthodontists often use two-dimensional imaging techniques. The assessment is based on CBCT images and dental cast models to overcome these limitations; however, the evaluation of soft tissues remains complex. The aim of the prese...
New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimo...
Pacheco, Rita I.; Cristo, Maria I.; Anjo, Sandra I.; Silva, Andreia F.; Sousa, Maria Inês; Santos Tavares, Renata; Sousa, Ana PaulaThe global trend of rising (male) infertility is concerning, and the unidentifiable causes in half of the cases, the so-called unknown origin male infertility (UOMI), demands a better understanding and assessment of both external/internal factors and mechanisms potentially involved. In this work, it was our aim to obtain new insight on UOMI, specifically on idiopathic (ID) and Unexplained male infertility (UMI)...
Development of an in chemico high-throughput screening method for the identific...
Ferreira, Isabel; Brites, Gonçalo; Silva, Ana; Caramelo, Francisco; Oliveiros, Bárbara; Neves, Bruno Miguel; Cruz, Maria TeresaIt is well established that chemical-peptide conjugation represents the molecular initiating event (MIE) in skin sensitization. This MIE has been successfully exploited in the development of in chemico peptide reactivity assays, with the Direct Peptide Reactivity Assay (DPRA) being validated as a screening tool for skin sensitization hazard as well as an OECD test guideline. This test relies on the use of a hig...