3 documents found, page 1 of 1
Urinary volatile metabolomic biomarkers for detection of bladder cancer
Carapito, Ângela; Teixeira-Marques, Ana; Jerónimo, Carmen; Henrique, Rui; A. Roque, Ana Cecília; Carvalho, Félix; Pinto, Joana; Guedes de Pinho, PaulaBackground: Early detection of bladder cancer (BC) is necessary for improved outcomes, but current diagnostic methods may lack the necessary sensitivity. Metabolomics, particularly the analysis of urinary volatile organic compounds (VOCs), offers a promising, non-invasive approach to BC detection [1,2]. Objective: The study aimed to investigate potential urinary biomarkers for the detection and staging of ...
Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogram...
Afonso, Julieta Alexandra Pereira; Matos, Ana Catarina Barbosa; Silvestre, Ricardo Jorge Leal; Pereira-Vieira, Joana; Gonçalves, Samuel MartinsAdvanced urothelial bladder cancer (UBC) patients are tagged by a dismal prognosis and high mortality rates, mostly due to their poor response to standard-of-care platinum-based therapy. Mediators of chemoresistance are not fully elucidated. This work aimed to study the metabolic profile of advanced UBC, in the context of cisplatin resistance. Three isogenic pairs of parental cell lines (T24, HT1376 and KU1919)...
A importância do humor vítreo em análises post-mortem
Carapito, Ângela; Rodrigues, Francisco; Coelho, PatriciaIntrodução As análises bioquímicas realizadas ao humor vítreo constituem hoje uma mais valia para a toxicologia forense e em análises post-mortem ajudando a determinar a causa de morte e a estimar o intervalo post-mortem, assim como a elucidar casos forenses. O humor vítreo é uma substância gelatinosa contida na parte posterior do olho, constituído por 99% de água. Devido à sua composição e às suas característi...