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Safe-by-design development of a topical patch for drug delivery
Vaz, Mafalda B.; Vitorino, Carla; Sousa, João J. S.Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a ...
Development of levofloxacin-loaded PLGA microspheres of suitable properties for...
Gaspar, Marisa C.; Pais, Alberto A. C. C.; Sousa, João J. S.; Brillaut, Julien; Olivier, Jean-ChristopheAerosol antibiotics are an interesting alternative to oral or intravenous therapy in Cystic Fibrosis lung infections. Levofloxacin (LVX) inhaled solution is already an effective option. In this study, the aim was the development of LVX-loaded PLGA microspheres (MS) for pulmonary administration as a dry powder. MS were prepared, for the first time, by a modified double emulsion solvent evaporation method with pr...
Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of imme...
Gaspar, M. C.; Grégoire, N.; Sousa, João J. S.; Pais, Alberto A. C. C.; Lamarche, I.; Gobin, P.; Olivier, J.-C.; Marchand, S.; Couet, W.A comparative pharmacokinetic study was conducted in rats after intratracheal aerosolization of levofloxacin, as a solution, as immediate-release chitosan microspheres or as sustained-release PLGA microspheres. A pharmacokinetic model was constructed to model levofloxacin concentrations both in plasma and in the lung epithelial lining fluid (ELF). The plasma and ELF experimental concentration profiles versus ti...
Films based on chitosan polyelectrolyte complexes for skin drug delivery: Devel...
Silva, Cláudia L.; Pereira, Jorge C.; Ramalho, Amílcar; Pais, Alberto A. C. C.; Sousa, João J. S.Novel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interact...
Aggregation and gelation in hydroxypropylmethyl cellulose aqueous solutions
Silva, Sérgio M. C.; Pinto, Fátima V.; Antunes, Filipe E.; Miguel, Maria G.; Sousa, João J. S.; Pais, Alberto A. C. C.http://www.sciencedirect.com/science/article/B6WHR-4TC923M-1/2/012a59092ead1ce270813efcf98c1fb2
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Os...
Costa-Balogh, Fátima O.; Åberg, Christoffer; Sousa, João J. S.; Sparr, EmmaIn this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear tr...