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Workshop to scope and preselect indicators for criterion D3C3 under MSFD decisi...

Armelloni, Enrico; Bolund, Elisabeth; Canal, Gema; Cardinale, Massimiliano; Coscia, Ilaria; Croll, Jasper; Balic, Daria Ezgeta; Falsone, Fabio

The workshop to scope and preselect indicators for Descriptor 3 criterion 3 under MSFD Commission Decision (EU) 2017/848 (WKD3C3SCOPE) provided a platform for experts from the EU member states and relevant regional bodies to meet and support development and progress the assessment methodology, based on a request by the EC (DGENV). WKD3C3SCOPE is the first of a series of three workshops (WKD3C3THRESHOLDS and WKS...


Effects of sample handling and cultivation bias on the specificity of bacterial...

Hardoim, Cristiane; Cardinale, Massimiliano; Cucio, Ana C. B.; Esteves, Ana; Berg, Gabriele; Xavier, Joana R.; Cox, C. J.; Costa, Rodrigo

Complex and distinct bacterial communities inhabit marine sponges and are believed to be essential to host survival, but our present-day inability to domesticate sponge symbionts in the laboratory hinders our access to the full metabolic breadth of these microbial consortia. We address bacterial cultivation bias in marine sponges using a procedure that enables direct comparison between cultivated and uncultivat...


Bamboo fibre processing: insights into hemicellulase and cellulase substrate ac...

Fu, Jiajia; Nyanhongo, Gibson S.; Silva, Carla Manuela Pereira Marinho da; Cardinale, Massimiliano; Prasetyo, E. N.; Yu, Chongwen; Paulo, Artur Cavaco

A biological approach for degumming bamboo substrates has been assessed. The ability of various commercially available enzymes, including cellulase, xylanase, pectinase and mannanase, to hydrolyze bamboo powders was investigated. In addition, a commercial cellulase preparation was applied onto bamboo fibre bundles obtained by natural retting. It was found that almost all enzymes applied can use bamboo material ...


Folic acid-functionalized human serum albumin nanocapsules for targeted drug de...

Rollett, Alexandra; Reiter, Tamara; Nogueira, Patrícia; Cardinale, Massimiliano; Loureiro, Ana; Gomes, Andreia C; Paulo, Artur Cavaco

Activated synovial macrophages play a key role in Rheumatoid Arthritis (RA). Recent studies have shown that folate receptor beta (FRβ) is specifically expressed by activated macrophages. Therefore a folate-based nanodevice would provide the possibility of delivering therapeutic agents to activated macrophages without affecting normal cells and tissues. This study shows for the first time the sonochemical prepar...


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