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Analytical validation and algorithm improvement of HepatoPredict kit to assess ...
Gonçalves-Reis, Maria; Proença, Daniela; Frazão, Laura P.; Neto, João L.; Silva, Sílvia; Pinto-Marques, Hugo; Pereira-Leal, José; Cardoso, JoanaFunding Information: The authors wish to thank to the European Innovation Council for having partially financed this work with a grant under the EIC Accelerator scheme (Contract Nº946364). The authors also thank the patients, Neuralshift, and the pathology team from the Curry Cabral Hospital headed by António Figueiredo, with a special mention to Clara Rodrigues. Moreover, the authors particularly acknowledge t...
BRCA1 VUS
Lourenço, Rita Adubeiro; Lança, Miguel; Monteiro Gil, Octávia; Cardoso, Joana; Lourenço, Teresa; Pereira-Leal, José; Rodrigues, António SebastiãoGenetic testing for susceptibility genes through next‑generation sequencing (NGS) has become a widely used technique. Using this, a number of genetic variants have been identified, several of which are variants of unknown significance (VUS). These VUS can either be pathogenic or benign. However, since their biological effect remains unclear, functional assays are required to classify their functional nature. As...
Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota
Marques, Cláudia; Dinis, Liliana; Barreiros Mota, Inês; Morais, Juliana; Ismael, Shámila; Pereira-Leal, José; Cardoso, Joana; Ribeiro, PedroFunding This work was supported by ERDF through the operation POCI-01−0145-ERDF-007746 funded by the Programa Operacional Competitividade e Internacionalização − COMPETE2020 and by FCT - Fundação para a Ciência e a Tecnologia, IP national support through CINTESIS, R&D Unit (UIDB/4255/2020), CHRC (UIDP/04923/2020 and UIDB/04923/2020) and through the project reference PTDC/BAA-AGR/7419/2020.; Gut microbiota m...
A Gene Expression Signature to Select Hepatocellular Carcinoma Patients for Liv...
Pinto-Marques, Hugo; Cardoso, Joana; Silva, Sílvia; Neto, João L; Gonçalves-Reis, Maria; Proença, Daniela; Mesquita, Marta; Manso, André; Carapeta, SaraCopyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.; OBJECTIVE: To propose a new decision algorithm combining biomarkers measured in a tumor biopsy with clinical variables, to predict recurrence after liver transplantation (LT). SUMMARY BACKGROUND DATA: Liver cancer is one of the most frequent causes of cancer-related mortality. LT is the best treatment for hepatocellular carcinoma (HCC) pa...