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Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer pa...
Ribeirinho-Soares, S; Pádua, D; Amaral, AL; Valentini, E; Azevedo, D; Marques, C; Barros, R; Macedo, F; Mesquita, P; Almeida, RBackground: Colorectal cancer (CRC) remains a serious health concern worldwide. Despite advances in diagnosis and treatment, about 15 to 30% of stage II CRC patients subjected to tumor resection with curative intent, develop disease relapse. Moreover, the therapeutic strategy adopted after surgery is not consensual for these patients. This supports the imperative need to find new prognostic and predictive bioma...
COVID-19 Management in Clinical Dental Care Part III: Patients and the Dental O...
Melo, P; Manarte-Monteiro, P; Veiga, N; de Almeida, AB; Mesquita, PThe coronavirus 2019 (COVID-19) pandemic dramatically changed all aspects of life. In the context of clinical dental care, a significant number of new recommendations have been implemented to comply with public health policies, ensuring the safety of dental care professionals, staff, and patients and preventing further spread of the virus. This article is the third in a series of 3 on the management of COVID-19...
Inhibition of CXCR2 Plays a Pivotal Role in Re-Sensitizing Ovarian Cancer to Ci...
Henriques, TB; Santos, DZ; Guimarães, IDS; Tessarollo, NG; Lyra-Junior, PCM; Mesquita, P; Pádua, D; Amaral, AL; Cavadas, B; Pereira, L; Silva, IVcDNA microarray data conducted by our group revealed overexpression of CXCL2 and CXCL8 in ovarian cancer (OC) microenvironment. Herein, we have proven that the chemokine receptor, CXCR2, is a pivotal molecule in re-sensitizing OC to cisplatin, and its inhibition decreases cell proliferation, viability, tumor size in cisplatinresistant cells, as well as reversed the overexpression of mesenchymal epithelium trans...
The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Ce...
Pádua, D; Figueira, P; Ribeiro, I; Almeida, R; Mesquita, PGastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs became a crucial goal for cancer treatment. The identification of these cells has been performed by using cell-surfac...
A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to m...
Pádua, D; Barros, R; Amaral, AL; Mesquita, P; Freire, AF; Sousa, M; Maia, AF; Caiado, I; Fernandes, H; Pombinho, AR; Pereira, CF; Almeida, RGastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 acti...
Expression and clinical relevance of SOX9 in gastric cancer
Mesquita, P; Freire, AF; Lopes, N; Gomes, R; Azevedo, D; Barros, R; Pereira, B; Cavadas, B; Pópulo, H; Boaventura, P; David, L; Pereira, L; Almeida, RGastric cancer is one of the most frequent tumours and the third leading cause of cancer-related death worldwide. The investigation of new biomarkers that can predict patient outcome more accurately and allow better treatment and follow-up decisions is of crucial importance. SOX9 (sex-determining region Y (SRY)-box 9) is a regulator of cell fate decisions in embryogenesis and adulthood. Here, we sought to ascer...
Vinhos que pensam - parte i|iii: gestão do vigor vegetativo da vinha a partir d...
Marques da Silva, JR; Terron, JM; Sousa, A; Mesquita, P; Vieira, F; Blanco, J; Serrano, J; Silva, LL; Coelho, R; Alexandre, C; Baptista, FVinhos que pensam - parte i|iii: gestão do vigor vegetativo da vinha a partir de sensores ativos multiespectrais próximos
Vinhos que pensam - parte ii|iii: utilização da condutividade elétrica aparente...
Marques da Silva, JR; Terron, JM; Sousa, A; Mesquita, P; Vieira, F; Blanco, J; Serrano, J; Silva, LL; Coelho, R; Alexandre, C; Baptista, FVinhos que pensam - parte ii|iii: utilização da condutividade elétrica aparente do solo na instalação e gestão das culturas: exemplificação na vinha
OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcino...
Raquel Almeida; Almeida, J; Shoshkes, M; Mendes, N; Mesquita, P; Silva, E; Van Seuningen, I; Celso Reis; Santos-Silva F; David LIntestinal metaplasia (IM) is a preneoplastic lesion of the stomach in which there is transdifferentiation of the gastric mucosa to an intestinal phenotype. The caudal-related homeobox gene CDX2 encodes an intestine-specific transcription factor crucial for the regulation of proliferation and differentiation of intestinal cells. In addition, CDX2 is involved in the induction of IM in the stomach. The aim of thi...