2 documents found, page 1 of 1
Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics
Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; Geraldes, Carlos F. G. C.Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNP...
miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP ...
Barros-Viegas, Ana Teresa; Carmona, Vitor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria S.; Cunha, Pedro; Almeida, Luís Pereira deAlzheimer's disease (AD) is the most common form of dementia worldwide, characterized by progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness and death. Recently, microRNA (miRNA) dysfunction has been associated with increased production and impaired clearance of amyloid-β (Aβ) peptides, whose accumulation is one of the most well-known pathophysiological markers of this dise...