In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage-cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
O presente estudo tem como objetivo avaliar os motivos associados à omissão da insulina como estratégia de perda de peso e as diferenças entre adultos com Diabetes Mellitus tipo 1 (DM1) com e sem diabulimia em relação à imagem corporal e comportamento alimentar. A amostra desta investigação é constituída por 34 indivíduos com DM1, com idades com preendidas entre os 18 anos e os 55 anos (M=35.14, DP=10.08). Os p...
Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-γ in tumor immune surveillance, IFN-γ-based therapies undergoing clinical trials have been of...