16 documents found, page 1 of 2
Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Pr...
Fevereiro-Martins, M; Aguiar, L; Inácio, Â; Cardoso, C; Santos, AC; Marques-Neves, C; Guimarães, H; Pinto, R; Bicho, MBackground/Objectives: Retinopathy of prematurity (ROP) is a leading cause of vision impairment in preterm infants, with its pathogenesis linked to oxygen exposure. Red blood cell (RBC) transfusions, commonly performed in neonatal intensive care units (NICUs), reduce fetal hemoglobin (HbF) fraction, altering oxygen dynamics and potentially contributing to ROP. We aimed to investigate the relationship between RB...
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, PC; Soares, ML; Ferreira, AC; Santos, RF; Cavaleiro Rufo, J; Vasconcelos, D; Carvalho, A; Guimarães, S; Vasques-Nóvoa, F; Cardoso, C; Melo, NIntroduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood....
Predictors of survival and technical success of bronchoscopic interventions in ...
Freitas, C; Serino, M; Cardoso, C; Saleiro, S; Vaz, AP; Bastos, HN; Morais, A; Magalhães, A; Fernandes, GBackground: Malignant airway obstruction (MAO) leads to quality of life impairment and increased mortality. Interventional bronchoscopy allows airway patency restoring, leading to a better survival. We investigated predictors of survival and successful bronchoscopic intervention among MAO patients. Methods: This observational prospective study enrolled 100 patients who were newly diagnosed with MAO. Survival wa...
Hipertensão pulmonar na infecção VIH/SIDA: uma doença rara
Cardoso, C; Trigo, D; Pacheco, PA Hipertensão pulmonar (HTP) é uma patologia rara mas que condiciona elevada morbilidade e mortalidade. É conhecida a sua associação com o Vírus da Imunodeficiência Humana (VIH), mas muitos dos mecanismos implicados na sua patogénese bem como o impacto da terapêutica antiretroviral (TARV) no tratamento e prognóstico desta doença ainda se encontram por definir. Apresenta-se um caso clínico de uma doente de 62 an...
Multicenter survey on the use of device-assisted enteroscopy in Portugal
Pinho, R; Mascarenhas-Saraiva, M; Mão-de-Ferro, S; Ferreira, S; Almeida, N; Figueiredo, P; Rodrigues, A; Cardoso, H; Marques, M; Rosa, B; Cotter, JDevice-assisted enteroscopies (DAEs) are recent endoscopic techniques that enable direct endoscopic small-bowel evaluation.
Multicenter survey on the use of device-assisted enteroscopy in Portugal
Pinho, R; Mascarenhas-Saraiva, M; Mão-de-Ferro, S; Ferreira, S; Almeida, N; Figueiredo, P; Rodrigues, A; Cardoso, H; Marques, M; Rosa, B; Cotter, JBACKGROUND: Device-assisted enteroscopies (DAEs) are recent endoscopic techniques that enable direct endoscopic small-bowel evaluation. OBJECTIVE: The objective of this article is to evaluate the implementation of DAEs in Portugal and assess the main indications, diagnoses, diagnostic yield, therapeutic yield and complication rate. METHODS: We conducted a multicenter retrospective series using a national Web-ba...
Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic cond...
Kostic, I; Fidalgo-Carvalho, I; Aday, S; Vazão, H; Carvalheiro, T; Grãos, M; Duarte, A; Cardoso, C; Gonçalves, L; Carvalho, L; Paiva, A; Ferreira, LSeveral clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery. Herein we show that lysophosphatidic acid (LPA)-treated human umbilical cord blood-derived CD34(+) cells cultured under hypoxic and serum-deprived conditions present 2.2-fold and 1.3-fold higher survival relatively to...
Adenocarcinoma do Íleon. Uma Entidade Rara e de Diagnóstico Tardio
Nabais, C; Salústio, R; Bispo, C; Sousa, F; Porto, E; Cardoso, C; Silva, G; Caldeira Fradique, AINTRODUÇÃO A neoplasia do intestino delgado é uma entidade rara, apresentando uma incidência anual de cerca de 2.1 casos por 100,000 pessoas, sendo o adenocarcinoma, o segundo tipo histológico mais frequente (em 33% dos casos). A localização distal deste tipo de tumor é menos habitual, o que torna o adenocarcinoma do íleon num evento invulgar. A raridade deste tipo de patologia, associada a uma apresentação clí...
Adenocarcinoma of the Ileum: A Rare and Challenging Entity
Nabais, C; Salústio, R; Sousa, F; Porto, E; Cardoso, C; Caldeira Fradique, AINTRODUCTION: Primary small bowel malignancy is unusual and accounts for 1-3% of all gastrointestinal tract neoplasms. Adenocarcinoma is one of the most common histologic types, but its frequency decreases with more distal locations. Its clinical presentation is nonspecific and is usually associated with advanced disease, which contributes to delayed diagnosis. PRESENTATION OF CASE: A 66-year-old woman was admi...
Custo-Efetividade do Liraglutido: Comparação de Custos e Benefícios Relativamen...
Cardoso, C; Silva, C; Silva Nunes, J; Fonseca, AIntrodução: O liraglutido é um agonista do glucagon-like peptide-1 para tratamento da diabetes tipo 2, associado a antidiabéticos orais ou insulina basal. Objectivo: Determinar o custo-utilidade do liraglutido 1,2 mg/dia versus insulina glargina 24 UI/dia e sitagliptina 100 mg/dia, durante 35 anos, na perspetiva do Serviço Nacional de Saúde, seguindo orientações oficiais. Materiais e Métodos: O modelo farmacoec...