2 documents found, page 1 of 1
Microglial Rac1 is essential for experience-dependent brain plasticity and cogn...
Socodato, Renato; Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C.S.; Tedim-Moreira, Joana; Ferreira, João Galvão; Canedo, TeresaMicroglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drive...
Deciphering the astrocytic and synaptic changes under chronic alcohol exposure ...
Rodrigues, Ana Margarida; Canedo, Teresa; Terceiro, Ana Filipa; Tedim-Moreira, Joana; Silva, Ana Isabel; Magalhães, Ana; Relvas, JoãoDrug abuse is characterized by a compulsive and persistent drug-seeking behaviour, despite the harmful emotional, physical and social consequences. Our laboratory has previously found that the neuronal-glial crosstalk is critical in relaying the changes caused by acute exposure to psychoactive drugs through neuroimmune mechanisms. We have also reported that microglia can engulf postsynaptic components in the pr...