44 documents found, page 1 of 5
A blood-free diet to rear anopheline mosquitoes
Marques, Joana; Cardoso, João CR; Félix, Rute C.; Power, Deborah; Silveira, HenriqueMalaria research requires large-scale breeding and production conditions for mosquitoes (Anopheles spp.) in captivity. The sustainable and reliable production of mosquitoes is currently inhibited by the supply of fresh vertebrate blood. Alternatives to blood are required to promote efficient control strategies for malaria and other vector borne diseases that are transmitted by blood feeding insects. With this i...
Holothurians have a reduced GPCR and odorant receptor-like repertoire compared ...
Marquet, Nathalie; Cardoso, João CR; Louro, Bruno; Fernandes, Stefan; Silva, Sandra; Canario, AdelinoSea cucumbers lack vision and rely on chemical sensing to reproduce and survive. However, how they recognize and respond to environmental cues remains unknown. Possible candidates are the odorant receptors (ORs), a diverse family of G protein-coupled receptors (GPCRs) involved in olfaction. The present study aimed at characterizing the chemosensory GPCRs in sea cucumbers. At least 246 distinct GPCRs, of which c...
Corticotropin-Releasing Hormone (CRH) gene family duplications in Lampreys corr...
Cardoso, João CR; Bergqvist, Christina A.; Larhammar, DanThe ancestor of gnathostomes (jawed vertebrates) is generally considered to have undergone two rounds of whole genome duplication (WGD). The timing of these WGD events relative to the divergence of the closest relatives of the gnathostomes, the cyclostomes, has remained contentious. Lampreys and hagfishes are extant cyclostomes whose gene families can shed light on the relationship between the WGDs and the cycl...
Cartilage acidic protein 1 promotes increased cell viability, cell proliferatio...
Letsiou, Sophia; Félix, Rute; Cardoso, João CR; L, Anjos; Mestre, Ana L G; H, Gomes; Power, DeborahCartilage acidic protein 1 (CRTAC1) is an extracellular matrix protein of human chondrogenic tissue that is also present in other vertebrates, non-vertebrate eukaryotes and in some prokaryotes. The function of CRTAC1 remains unknown but the protein's structure indicates a role in cell-cell or cell-matrix interactions and calcium-binding. The aim of the present study was to evaluate the in vitro effects of hCRTA...
Dilution of seawater affects the Ca2 + transport in the outer mantle epithelium...
Sillanpää, J. Kirsikka; Cardoso, João CR; Félix, Rute; Anjos, Liliana; Power, Deborah; Sundell, KristinaVarying salinities of coastal waters are likely to affect the physiology and ion transport capabilities of calcifying marine organisms such as bivalves. To investigate the physiological effect of decreased environmental salinity in bivalves, adult oysters (Crassostrea gigas) were exposed for 14 days to 50% seawater (14) and the effects on mantle ion transport, electrophysiology and the expression of Ca2+ transp...
Stanniocalcin-1 protein expression profile and mechanisms in proliferation and ...
Costa, Bruna Pasqualotto; Schein, Vanessa; Zhao, R.; Santos, Andressa Schneiders; Kliemann, Lucia Maria; Nunes, Fernanda Bordignon; Cardoso, João CRProstate cancer (PCa) is one of the most prevalent male tumours. Stanniocalcin-1 (STC1) is a glycoprotein and, although the role of STC1 in human cancer is poorly understood, it is suggested to be involved in the development and progression of different neoplasms. This study investigated the protein expression profile of STC1 in PCa and benign prostatic hyperplasia (BPH) samples and STC1 signalling during cell ...
The calcitonin-like system is an ancient regulatory system of biomineralization
Cardoso, João CR; Félix, Rute C.; Ferreira, Vinícius; Peng, Maoxiao; Zhang, Xushuai; Power, DeborahBiomineralization is the process by which living organisms acquired the capacity to accumulate minerals in tissues. Shells are the biomineralized exoskeleton of marine molluscs produced by the mantle but factors that regulate mantle shell building are still enigmatic. This study sought to identify candidate regulatory factors of molluscan shell mineralization and targeted family B G-protein coupled receptors (G...
Corrigendum: tracing the origins of the Pituitary Adenylate-Cyclase Activating ...
Cardoso, João CR; Garcia, Manuel; Power, DeborahA Corrigendum on Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) by Cardoso, J. C. R., Garcia, M. G., and Power, D. M. (2020). Front. Neurosci. 14:366. doi: 10.3389/fnins.2020.00366 In the original article, there was amistake in the legend for Table 1 as published. The table describes nomenclature for both vertebrates and non-vertebrates. In the original article, there was ...
Tracing the origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (...
Cardoso, João CR; Garcia, Manuel G.; Power, DeborahPituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide regulates neurotransmitter release, intestinal motility, metabolism, cell division/differentiation, and immunity. In vertebrates, PACAP has a specific receptor (PAC1) but it can also activate the Vasoactive Intestinal Peptide receptors (VPAC1 and V...
Deciphering mollusc shell production: the roles of genetic mechanisms through t...
Clark, Melody S.; Peck, Lloyd S.; Arivalagan, Jaison; Backeljau, Thierry; Berland, Sophie; Cardoso, João CR; Caurcel, Carlos; Chapelle, GauthierMost molluscs possess shells, constructed from a vast array of microstructures and architectures. The fully formed shell is composed of calcite or aragonite. These CaCO3 crystals form complex biocomposites with proteins, which although typically less than 5% of total shell mass, play significant roles in determining shell microstructure. Despite much research effort, large knowledge gaps remain in how molluscs ...