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Prognostic role and clinicopathological features of SMAD4 gene mutation in panc...

Rodrigues, Tânia; Albuquerque, Joana; Cardoso, Joana; Sousa-Ferreira, Ivo; Martins, João Paulo; Coelho, José Luís Passos

Purpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in pancreatic cancer to aid in the design of therapeutic strategies. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and the...


Prognostic role and clinicopathological features of SMAD4 gene mutation in panc...

Rodrigues, Tânia; Albuquerque, Joana; Cardoso, Joana; Sousa-Ferreira, Ivo; Martins, João Paulo; Coelho, José Luís Passos

Purpose: The prognostic value of SMAD4 in pancreatic cancer has been evaluated in several studies. However, the conclusions remain controversial. Therefore, we aimed to evaluate the prognostic value of the SMAD4 gene in pancreatic cancer to aid in the design of therapeutic strategies. Methods: This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria and the...


Comparing outcomes after open and endovascular chronic mesenteric ischemia reva...

Fidalgo, Helena; Ribeiro, Tiago; Pais, Fábio; Cardoso, Joana; Tavares, Carolina; Correia, Ricardo; Gonçalves, Daniela; Ferreira, Maria Emília

INTRODUCTION: Chronic mesenteric ischemia (CMI) is a rare but life-threatening disease. This study aimed to analyze the safety and effectiveness of open (OR) and endovascular (ER) revascularization and respective outcomes in a consecutive series of CMI patients. METHODS: From 2013 to 2023, all CMI patients treated with OR and ER were retrospectively identified. Demographics, comorbidities, clinical presentation...

Date: 2025   |   Origin: Angiologia e Cirurgia Vascular

PratyOmics - Metabolómica da planta para o controlo do nemátode das lesões radi...

Barbosa, Pedro; Costa, Marina; Espada, Margarida; Teixeira, Dora; Brás, Teresa; Duarte, Fátima; Figueiredo, Joana; Cardoso, Joana; Esteves, Ivânia

O nemátode-das-lesões-radiculares (NLR), Pratylenchus penetrans, é um endoparasita migratório que afeta culturas agrícolas economicamente importantes, como a batata, estando atualmente presente na lista de pragas reguladas não sujeitas a quarentena A2 da União Europeia (UE 2016/2031). Em alguns países europeus, como Portugal, esta espécie foi detetada em campos de produção de batata estando relacionada com o se...


Chronic limb-threatening ischemia under the age of 50 – a single-center 12-year...

Gueifão, Inês; Quintas, Anita; Soares Ferreira, Rita; Pais, Fábio; Ribeiro, Tiago; Cardoso, Joana; Fidalgo, Helena; Ferreira, Maria Emília

INTRODUCTION: Premature peripheral artery disease (PAD), defined as occurring before or at the age of 50, is a poorly studied subset of PAD due to its low incidence. It has been associated with a higher risk of progression to chronic limb-threatening ischemia (CLTI), major adverse limb events and mortality. Etiology is multifactorial, with genetics and environmental causes at play, with the most common risk fac...

Date: 2025   |   Origin: Angiologia e Cirurgia Vascular

Chronic Limb-Threatening Ischemia Under the Age of 50 – a Single-Center 12-Year...

Gueifão, Inês; Quintas, Anita; Soares Ferreira, Rita; Pais, Fábio; Ribeiro, Tiago; Cardoso, Joana; Fidalgo, Helena; Ferreira, Maria Emilia

INTRODUCTION: Premature peripheral artery disease (PAD), defined as occurring before or at the age of 50, is a poorly studied subset of PAD due to its low incidence. It has been associated with a higher risk of progression to chronic limb-threatening ischemia (CLTI), major adverse limb events and mortality. Etiology is multifactorial, with genetics and environmental causes at play, with the most common risk fac...


HepatoPredict Accurately Selects Hepatocellular Carcinoma Patients for Liver Tr...

Andrade, Rita; Perez-Rojas, Judith; da Silva, Sílvia Gomes; Miskinyte, Migla; Quaresma, Margarida C; Frazão, Laura P; Peixoto, Carolina

Background/objectives: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths rising worldwide. This is leading to an increased demand for liver transplantation (LT), the most effective treatment for HCC in its initial stages. However, current patient selection criteria are limited in predicting recurrence and raise ethical concerns about equitable access to care. This study aims to enhance pa...


Diagnosis and Predictors of Post-Implantation Syndrome Following Endovascular R...

F. Ribeiro, Tiago; Soares Ferreira, Rita; Bento, Rita; Pais, Fábio; Cardoso, Joana; Bastos Gonçalves, Frederico; Amaral, Carlos; Ferreira, Maria Emilia

INTRODUCTION: After endovascular aortic repair (EVAR), many patients develop a systemic inflammatory response called post-implantation syndrome (PIS). AAA and procedure-related characteristics have been linked with increased odds of developing this syndrome. Similarly, some short- and long-term consequences have been associated with PIS. This study aims to review the literature on the diagnosis and predictors o...


Fenestrated Physician-Modified Endografts (PMEGs) - a Viable Option for Urgent ...

Bento, Rita; Alves, Gonçalo; Rodrigues, Gonçalo; Garcia, Rita; Ribeiro, Tiago; Cardoso, Joana; Soares Ferreira, Rita; Ferreira, Maria Emilia

INTRODUCTION: Fenestrated and branched stent graft technology has come a long way over the past few years, enabling the treatment of complex juxtarenal aneurysms, thoracoabdominal aneurysms, and arch pathologies. Many innovations have been developed, namely device and delivery optimization and technical tricks. These concepts have proven to work well when there is sufficient time to plan and manufacture a custo...


Intravascular Lithotripsy For Severe Peripheral Artery Calcification – A 3-Year...

Gueifão, Inês; Correia, Ricardo; Quintas, Anita; Ribeiro, Tiago; Cardoso, Joana; Fidalgo, Helena; Figueiredo, Adriana; Ferreira, Maria Emília

Introduction: Severe arterial calcification is a challenging limitation in endovascular procedures leading to worse success rates and outcomes. Conventional balloon angioplasty may provide limited luminal gain, calling for adjunctive strategies of plaque modification, such as intravascular lithotripsy (IVL). The aim of this study is to describe our institutional experience with IVL in the treatment of periphera...


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