In several industrial fields, environmental and operational data are acquired with numerous purposes, potentially generating a huge quantity of data containing valuable information for management actions. This work proposes a methodology for clustering time series based on the K-medoids algorithm using a convex combination of different time series correlation metrics, the COMB distance. The multidimensional sca...
The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. Here, we analyzed the capacity of monocyte-derived dendriti...
Introduction Osteoarthritis (OA) is one of the main reasons for early retirement of sport horses and despite new technologies, radiographic examination is still the most commonly used method of diagnosis. Radiographic changes due to OA in horses are mainly found in the distal limb and tarsal joints (Baccarin et al., 2012). The objectives of the present study were to identify the most frequent radiological findi...
Introdução e objetivos A avaliação radiológica do sistema locomotor faz atualmente parte da avaliação de rotina em equinos, com o objetivo de diagnosticar alterações que possam comprometer a vida desportiva do cavalo. Presentemente existem alguns estudos sobre os achados radiográficos em cavalos de desporto, sendo que, os mais comuns são relacionados com a presença de osteoartrite (OA). O objetivo deste estudo ...
Chromothripsis is an extreme form of complex chromosomal rearrangement (CCR), characterized by a localized shattering and random reassembly of genomic fragments. The aim of this study is the characterization at sequence-level resolution of a cytogenetically identified CCR 46,XY,t(7;14)(q21.13;q31),inv(15)(q21.2q26.1) associated with cognitive disabilities, and intrafamilial phenotype-genotype correlation analys...