3 documents found, page 1 of 1
CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effe...
Cardoso, Marcos S.; Gonçalves, Rute; Oliveira, Liliana; Silvério, Diogo; Téllez, Erica; Paul, Tony; Sarrias, Maria Rosa; Carmo, Alexandre M.Tuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of the deadliest diseases to humankind. Understanding the immune mechanisms underlying protection or pathology in TB is key to uncover the much needed innovative approaches to tackle TB. The scavenger receptor cysteine-rich molecule CD5 antigen-like (CD5L) has been associated with TB, but whether and how CD5L shapes the im...
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common ...
Resende, Mariana; Cardoso, Marcos S.; Ribeiro, Ana R.; Flórido, Manuela; Borges, Margarida; Castro, António G.; Alves, Nuno L.; Cooper, Andrea M.IFN-gamma is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In this study, we used IFN-gamma reporter mouse models to search for additional cells capable of secreting this cytokine. We identified a novel and rare population of nonconventional IFN-gamma-producing cells of hematopoietic origin that were characterized by t...
Lack of the transcription factor hypoxia-inducible factor (HIF)-1α in macrophag...
Cardoso, Marcos S.; Silva, Tânia M.; Resende, Mariana; Appelberg, Rui; Borges, MargaridaThe establishment of mycobacterial infection is characterized by the formation of granulomas, which are well-organized aggregates of immune cells, namely, infected macrophages. The granuloma's main function is to constrain and prevent dissemination of the mycobacteria while focusing the immune response to a limited area. In some cases these lesions can grow progressively into large granulomas which can undergo ...