62 documents found, page 1 of 7
Current Advances in Mitochondrial Targeted Interventions in Alzheimer's Disease
Sousa, Tiago; Moreira, Paula I.; Cardoso, SusanaAlzheimer's disease is the most prevalent neurodegenerative disorder and affects the lives not only of those who are diagnosed but also of their caregivers. Despite the enormous social, economic and political burden, AD remains a disease without an effective treatment and with several failed attempts to modify the disease course. The fact that AD clinical diagnosis is most often performed at a stage at which th...
Childhood Obesity Surveillance Initiative: COSI Portugal 2022
Rito, Ana; Mendes, Sofia; Figueira, Inês; Faria, Maria do Carmo; Carvalho, Rita; Santos, Teresa; Cardoso, Susana; Feliciano, Elsa; Silvério, RosaO Childhood Obesity Surveillance Initiative (COSI)/Organização Mundial da Saúde (OMS) é o sistema europeu de vigilância nutricional infantil coordenado pelo Gabinete Regional Europeu da OMS. Tem como principal objetivo criar uma rede sistemática de recolha, análise, interpretação e divulgação de informação descritiva sobre as caraterísticas do estado nutricional infantil de crianças dos 6 aos 8 anos, que se tra...
A 96-wells fluidic system for high-throughput screenings under laminar high wal...
Fonseca, Catarina; Silvério, Vânia; Barata, David; Giese, Wolfgang; Gerhardt, Holger; Cardoso, Susana; Franco, ClaudioThe ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular network. Defective flow responses, in particular related to high flow conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, and neurodegenerative diseases. Yet, the molecular mechanisms involved in high flow...
Dark personality traits and online behaviors: Portuguese versions of Cyberstalk...
Leite, Ângela; Cardoso, Susana; Monteiro, Ana PaulaThe main objective of this study is to assess moderation effects of online behaviors between personality traits and addiction to Internet. To this end, four instruments were validated for Portuguese version through confirmatory factor analysis and exploratory factor analysis (Study 1) Multiple regression analysis was applied to examine the personality predictors of specific online behaviors while controlling fo...
A 96-wells fluidic system for high-throughput screenings under laminar high wal...
Fonseca, Catarina Gonçalves; Silvério, Vânia; Barata, David; Giese, Wolfgang; Gerhardt, Holger; Cardoso, Susana; Franco, Cláudio AreiasThe ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular network. Defective flow responses, in particular related to high flow conditions, have been associated with atherosclerosis, stroke, arteriovenous malformations, and neurodegenerative diseases. Yet, the molecular mechanisms involved in high flow...
Insulin-Induced Recurrent Hypoglycemia Up-Regulates Glucose Metabolism in the B...
Cardoso, Susana; Moreira, Paula I.Diabetes is a chronic metabolic disease that seriously compromises human well-being. Various studies highlight the importance of maintaining a sufficient glucose supply to the brain and subsequently safeguarding cerebral glucose metabolism. The goal of the present work is to clarify and disclose the metabolic alterations induced by recurrent hypoglycemia in the context of long-term hyperglycemia to further comp...
IGF1R Deficiency Modulates Brain Signaling Pathways and Disturbs Mitochondria a...
Cardoso, Susana; López, Icíar P.; Piñeiro-Hermida, Sergio; Pichel, José G.; Moreira, Paula I.Insulin-like growth factor 1 receptor (IGF1R)-mediated signaling pathways modulate important neurophysiological aspects in the central nervous system, including neurogenesis, synaptic plasticity and complex cognitive functions. In the present study, we intended to characterize the impact of IGF1R deficiency in the brain, focusing on PI3K/Akt and MAPK/ERK1/2 signaling pathways and mitochondria-related parameters...
Rapid and multiplex detection of nosocomial pathogens on a phage-based magnetor...
Cunha, Alexandra; Henriques, Raquel; Cardoso, Susana; Freitas, Paulo P.; Carvalho, Carla Alexandra Oliveira Cunha MedeirosAbstract Nosocomial or hospital-acquired infections (HAIs) have a major impact on mortality worldwide. Enterococcus and Staphylococcus are among the leading causes of HAIs and thus are important pathogens to control mainly due to their increased antibiotic resistance. The gold-standard diagnostic methods for HAIs are time-consuming, which hinders timely and adequate treatment. Therefore, the development of fast...
Functional health literacy : psychometric properties of the newest vital sign f...
Santos, Osvaldo; Stefanovska, Miodraga; Virgolino, Ana; Miranda, Ana Cristina; Costa, Joana; Fernandes, Elisabete; Cardoso, SusanaSelf-management of health requires skills to obtain, process, understand, and use health-related information. Assessment of adolescents’ functional health literacy requires valid, reliable, and low-burden tools. The main objective of this study was to adapt and study the psychometric properties of the Newest Vital Sign for the Portuguese adolescents’ population (NVS-PTeen). Classic psychometric indicators of re...
UPSA: avaliação do desempenho funcional nos diferentes estádios de declínio cog...
Cardoso, Susana; Ribeiro, Filipa Correia; Nunes, Maria Vânia SilvaIntrodução: A demência é uma síndrome clínica adquirida, caracterizada pelo declínio progressivo de várias funções cognitivas. Os défices são persistentes e têm gravidade suficiente para interferir nas relações sociais e na capacidade para realizar de um modo autónomo as actividades de vida diária. Vários estudos demonstraram que défices nas actividades instrumentais de vida diária (AIVD) predizem significativa...