12 documents found, page 1 of 2
Sex differences in axial spondyloarthritis: data from a Portuguese spondyloarth...
Cunha, RN; Sousa, E; Khmelinskii, N; Ávila, P; Couto, M; Seixas, MI; Martins, N; Bernardes, M; Martins, A; da Silva, AB; Lourenço, MH; Miguel, CBackground: Axial spondyloarthritis (axSpA), particularly ankylosing spondylitis was historically considered a male’s disease and has been under-recognized in women. Emerging evidence reveals sex differences in pathophysiology, disease presentation and therapeutic efficacy. Objective: To identify differences between sexes in a Portuguese cohort of patients with axSpA regarding clinical manifestations, disease a...
Portuguese Recommendations for the Use of Biological and Targeted Synthetic Dis...
Fernandes, BM; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Roxo Ribeiro, A; Quintal, A; Pereira, JP; Silva, L; Nóvoa, TS; Faustino, A; Vaz, CObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Portuguese recommendations for the use of biological and targeted synthetic dis...
Fernandes, Bruno Miguel; Guimarães, F; Almeida, DE; Neto, A; Tavares-Costa, J; Ribeiro, AR; Quintal, Alberto; Pereira, JP; Silva, L; Nóvoa, TSObjective: To update the recommendations for the treatment of rheumatoid arthritis (RA) with biological and targeted synthetic disease-modifying antirheumatic drugs (bDMARDs and tsDMARDs), endorsed by the Portuguese Society of Rheumatology (SPR). Methods: These treatment recommendations were formulated by Portuguese rheumatologists taking into account previous recommendations, new literature evidence and consen...
Differential modulation of cancellous and cortical distal femur by fructose and...
Pereira, C; Guede, D; Durães, C; Brandão, I; Silva, N; Passos, E; Bernardes, M; Monteiro, R; Martins, MJBone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without 10%-fructose, for 10 weeks. A sham-operated group drinking tap water was included (n = 6/group). Cancellous and cortical bone ...
Depression and anxiety in systemic lupus erythematosus: The crosstalk between i...
Figueiredo-Braga, M; Cornaby, C; Cortez, A; Bernardes, M; Terroso, G; Figueiredo, M; Mesquita, CS; Costa, L; Poole, BDepression and anxiety cause severe loss of quality of life for patients with systemic lupus erythematosus. The causes and factors that contribute to these psychological manifestations in lupus are difficult to disentangle. This study compared clinical, psychological, and demographic factors between lupus patients, depressed patients, and rheumatoid arthritis patients to discover lupus-specific contributors to ...
LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis p...
Bernardes, M; Durães, C; Oliveira, A; Martins, MJ; Lucas, R; Costa, L; Pereira, JG; Ramos, I; Machado, JC; Simões-Ventura, FRheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity.IntroductionIncreased bone re...
Influence of Biological Therapeutics, Cytokines, and Disease Activity on Depres...
Figueiredo-Braga, M; Cornaby, C; Cortez, A; Bernardes, M; Terroso, G; Figueiredo, M; Mesquita, CS; Costa, L; Poole, BPurpose: Rheumatoid arthritis (RA) is an often debilitating autoinflammatory disease. Patients with rheumatoid arthritis are often troubled by co-occurring depression or other psychological manifestations. RA patients have a variety of treatment options available, including biologicals that inhibit cytokines or immune cells. If these cytokines influence the psychological symptoms, then the use of cytokine inhib...
Correlation between physical markers and psychiatric health in a Portuguese sys...
Figueiredo-Braga, M; Cornaby, C; Bernardes, M; Figueiredo, M; Mesquita, CS; Costa, L; Poole, BBackground: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects a large number of people throughout the world. Anxiety, depression and fatigue are common symptoms of SLE that substantially contribute to decreased quality of life. This study investigates the interplay between physical and psychiatric manifestations of lupus. To this end, an SLE patient cohort was examined for correlat...
Vitamin D metabolism in human adipose tissue: Could it explain low Vitamin D st...
Cordeiro, A; Santos, Alejandro; Bernardes, M; Ramalho, A; Martins, MJObesity and a low vitamin D (VD) status, as well as a positive association between them, are prevalent worldwide. Additionally, a low VD status has been positively correlated with metabolic dysfunction (although not so convincingly as for obesity). The VD receptor (VDR) mediates VD biological actions in adipose tissue (AT), where VD can be activated or inactivated/degraded through specific hydroxylation steps. ...
Serum serotonin levels and bone in rheumatoid arthritis patients
Bernardes, M; Vieira, T; Lucas, R; Pereira, J; Costa, L; Simões-Ventura, F; Martins, MJIn rheumatoid arthritis (RA), a disease characterized by bone loss, increased levels of serotonin have been reported. Recent studies have demonstrated a role for circulating serotonin as a regulator of osteoblastogenesis, inhibiting bone formation. Thus, we measured serum serotonin levels (SSL) in a Portuguese sample of 205 RA patients and related these to anthropometric variables, disease parameters, serum bon...