4 documents found, page 1 of 1
Radiolabeling of cidofovir with technetium-99m and biodistribution studies
Arribada, Raquel Gregorio; Pereira, Nara Caroline; Cardoso, Valbert Nascimento; Cunha Júnior, Armando da Silva; Barros, André Luís Branco deRadiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and ...
PLA-PEG nanocapsules radiolabeled with 99mTechnetium-HMPAO : release properties...
Pereira, Maira Alves; Mosqueira, Vanessa Carla Furtado; Vilela, José Mário Carneiro; Andrade, Margareth Spangler; Ramaldes, Gilson AndradeThe present work describes the preparation, characterization and labelling of conventional and surface-modified nanocapsules (NC) with 99mTc-HMPAO. The size, size distribution and homogeneity were determined by photon correlation spectroscopy (PCS) and zeta potential by laser doppler anemometry. The morphology and the structural organization were evaluated by atomic force microscopy (AFM). The stability and rel...
Release profiles and morphological characterization by atomic force microscopy ...
Assis, Danielle Nogueira de; Mosqueira, Vanessa Carla Furtado; Vilela, José Mário Carneiro; Andrade, Margareth Spangler; Cardoso, Valbert NascimentoSeveral classes of antifungal have been employed in candidiasis treatment, but patients with advanced immunodeficiency can present unsatisfactory results after therapy. In these cases, high doses of drugs or the use of multiple agents are sometimes used, and hence increasing the risk of serious side effects. Considering theses difficulties, the encapsulation of antifungal agents in nanoparticulate carriers has ...
Translocation of 99mTc labelled bacteria after intestinal ischemia and reperfusion
João, Samir Assi; Alencar, Suelene Suassuna Silvestre de; Medeiros, Aldo da Cunha; Diniz, Simone Otília Fernandes; Cardoso, Valbert NascimentoIschemia and reperfusion of the small intestine disrupts gut barrier, causes bacterial translocation and activates inflammatory responses. An experimental study was planned to evaluate if 99mTc labelled Escherichia coli translocates to mesenteric lymph nodes, liver, spleen, lung and serum of rats submitted to mesenteric ischemia/reperfusion. Additionally, it was observed if the time of reperfusion influences th...