39 documents found, page 1 of 4
Development of a hydrophone for measuring the propagation of acoustic waves in ...
Pereira, Anabela; Cardoso, Vanessa Fernandes; Martins, Marcos Silva; Fernandes, Nuno Alexandre Tavares Campos; Carvalho, Óscar Samuel NovaisIn the past years, the prevalence of neurodegenerative diseases has in-creased, highlighting the urgent need to better understand and combat these diseases. Innovative ultrasound treatments have shown promising results but require further investigation, particularly regarding the pene-tration of acoustic waves into the brain. This work focus on developing a hydrophone to study acoustic wave penetration in biolo...
Bacterial nanocellulose as a versatile scaffold for biomedical applications: sy...
Melro, Liliana Sofia Silva Ferreira Pinto; Alves, Cátia Sofia Pereira; Fernandes, Marta Susana Machado; Rocha, Sofia Gomes; Mehravani, BehnazBacterial nanocellulose (BNC) consists of nanofibres of cellulose randomly entangled during their synthesis by particular bacterium cells during fermentation. Thus, it may be regarded as a unique three-dimensional of pure cellulose that is consolidated during the generation of the fibres by their microbiological factories. The metabolic synthesis and purification processes are approached, underscoring its poten...
Acylase-based coatings on sandblasted polydimethylsiloxane-based materials for ...
Silva, Cláudia A.; Moreira, Joana Isabel Machado; Fernandes, Marta Susana Machado; Zille, Andrea; Cardoso, Vanessa Fernandes; Nine, Md JulkerIndwelling medical devices, such as urinary catheters, often experience bacterial colonization, forming biofilms that resist antibiotics and the host's immune defenses through quorum sensing (QS), a chemical communication system. This study explores the development of antimicrobial coatings by immobilizing acylase, a quorum-quenching enzyme, on sandblasted polydimethylsiloxane (PDMS) surfaces. PDMS, commonly us...
Engineering a Point-of-Care Paper-Microfluidic electrochemical device applied t...
Gutiérrez-Capitán, Manuel; Sanchís, Ana; Carvalho, Estela O.; Baldi, Antonio; Vilaplana, Lluïsa; Cardoso, Vanessa Fernandes; Calleja, ÁlvaroHealth initiatives worldwide demand affordable point-of-care devices to aid in the reduction of morbidity and mortality rates of high-incidence infectious and noncommunicable diseases. However, the production of robust and reliable easy-to-use diagnostic platforms showing the ability to quantitatively measure several biomarkers in physiological fluids and that could in turn be decentralized to reach any relevan...
Graphene based printable conductive wax for low-power thermal actuation in micr...
Brito-Pereira, Ricardo; Ribeiro, Clarisse Marta Oliveira; Costa, Pedro Filipe Ribeiro; Correia, V.; Cardoso, Vanessa Fernandes; Lanceros-Mendez, S.Wax printing is one of the most widely used techniques to print hydrophobic barriers on hydrophilic microfluidic paper-based analytical devices (mu PADs) based on its simplicity, speed, and low cost, allowing large-scale production. Nonetheless, its function is just passive, without any action on fluids. Thus, this work proposes multifunctional hydrophobic composites based on conductive graphene nanoplatelets (...
Smart and multifunctional materials based on electroactive poly(vinylidene fluo...
Costa, Carlos Miguel Silva; Cardoso, Vanessa Fernandes; Martins, Pedro Libânio Abreu; Correia, Daniela Maria Silva; Gonçalves, Renato FerreiraFrom scientific and technological points of view, poly(vinylidene fluoride), PVDF, is one of the most exciting polymers due to its overall physicochemical characteristics. This polymer can crystalize into five crystalline phases and can be processed in the form of films, fibers, membranes, and specific microstructures, being the physical properties controllable over a wide range through appropriate chemical mod...
Modulation of myoblast differentiation by electroactive scaffold morphology and...
Ribeiro, Sylvie Oliveira; Marques-Almeida, Teresa; Cardoso, Vanessa Fernandes; Ribeiro, Clarisse Marta Oliveira; Lanceros-Mendez, S.The physico-chemical properties of the scaffold materials used for tissue regeneration strategies have a direct impact on cell shape, adhesion, proliferation, phenotypic and differentiation. Herewith, biophysical and biochemical cues have been widely used to design and develop biomaterial systems for specific tissue engineering strategies. In this context, the patterning of piezoelectric polymers that can provi...
Natural indigenous paper substrates for colorimetric bioassays in portable anal...
Brito-Pereira, Ricardo; Macedo, André Silva; Ribeiro, Clarisse Marta Oliveira; Cardoso, Vanessa Fernandes; Lanceros-Mendez, S.Point-of-care (POC) devices can provide inexpensive, practical, and expedited solutions for applications ranging from biomedicine to environmental monitoring. This work reports on the development of low-cost microfluidic substrates for POC systems suitable for analytical assays, while also satisfying the need for social and environmentally conscious practices regarding circular economy, waste reduction, and the...
Recent advances on cell culture platforms for In vitro drug screening and cell ...
Cardoso, Beatriz D.; Castanheira, Elisabete M. S.; Lanceros-Méndez, S.; Cardoso, Vanessa FernandesThe clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based on biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, the scientific community has improved cell-based drug screening assays and models. Those advances result in more informative biochemical assays and the development of 3D multicellular models to describe the bi...
Biodegradable polymer-based microfluidic membranes for sustainable point-of-car...
Brito-Pereira, Ricardo; Ribeiro, Clarisse Marta Oliveira; Lanceros-Méndez, S.; Cardoso, Vanessa FernandesMicrofluidic paper-based analytical devices (µPADs) have gained substantial attention as portable analytical devices in various (bio)technological fields, for being affordable, user-friendly, portable, energy efficient and for allowing multiplexed analysis. Although significant progress has been achieved, there is still need for improvement in terms of performance and sustainability. In this work, a biodegradab...