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Calciphylaxis in Pre-dialysis Chronic Kidney Disease: Case Report
Ferreira,André; Calado,Rebeca; Cardoso,José Carlos; Galvão,Ana; Alves,RuiAbstract Calciphylaxis is a rare life‑threatening vasculopathy resulting from calcium deposition in the arteriolar microvasculature of the deep dermis and subcutaneous adipose tissue, mainly occurring in end‑stage kidney disease (ESKD) treated with maintenance dialysis. Calciphylaxis in patients without ESKD is even rarer, which makes the diagnosis of calciphylaxis challenging in this population. In patients wi...
Case for diagnosis. A pruritic eruption of keratotic papules over the face and ...
Relvas,Maria; Calvão,Joana; Coutinho,Inês; Cardoso,José CarlosAbstract Generalized eruptive keratoacanthoma of Grzybowski is a rare variant of multiple keratoacanthomas counting with about 40 cases reported. It is a chronic and progressive disease for which none of the described therapeutic options has been entirely satisfactory. We report a case of an 83-year-old female who presented with a 3-month history of extremely pruritic, multiple, skin-coloured to erythematous to...
Multiple whitish papules on the posterior neck of an elderly woman,
Calvão,Joana; Ferreira,Bárbara Roque; Cardoso,José CarlosAbstract White fibrous papulosis of the neck is a rare entity, with fewer than 50 cases described. It is a benign pathology whose main interest lies in its broad differential diagnosis, especially with pseudoxanthoma elasticum. The authors report the case of a 77-year-old woman with multiple yellow-white monomorphic papules on the posterior cervical region, with years of evolution. Cutaneous biopsy revealed a n...
Case of Flexural Exanthema as a Presenting Sign for COVID-19
Oliveira,Raquel; Gonçalo,Margarida; Faria,Carlos; Donaire,David; Barbosa,Benilde; Cardoso,José Carlos; Julião,Maria José; Moura,José; Carvalho,ArmandoABSTRACT We report a case of a 84-year-old male hospitalized for bacterial pneumonia who, during hospitalization, developed a flexural exanthema in parallel with a positive swab for SARS-CoV-2. Supportive therapy was instituted, the rash disappeared in 7 days and the patient fully recovered. At the same time, two other cases of SARS-CoV-2 infection occurred in the same ward. Histopathology and immunohistochemis...
Metastatic Crohn’s disease despite infliximab therapy
Campos,Sara; Coutinho,Inês; Cardoso,José Carlos; Portela,FranciscoAbstract Metastatic Crohn’s disease is a rare extraintestinal manifestation of Crohn’s disease. It is characterized by polymorphic skin lesions formed by non-caseating granulomas located on anatomical sites distant from the gastrointestinal tract. We report a rare case of metastatic Crohn’s disease, simultaneously displaying multiple clinically heterogeneous cutaneous lesions, in a patient with previously diagn...
Non-melanoma skin cancer in Portuguese kidney transplant recipients - incidence...
Pinho,André; Gouveia,Miguel; Cardoso,José Carlos; Xavier,Maria Manuel; Vieira,Ricardo; Alves,RuiAbstract: Background: Cancer is currently among the three leading causes of death after solid organ transplantation and its incidence is increasing. Non-melanoma skin cancer - squamous cell carcinoma and basal cell carcinoma - is the most common malignancy found in kidney transplant recipients (KTRs). The incidence of non-melanoma skin cancer in KTRs has not been extensively studied in Portugal. Objectives: To ...
Histological variability and the importance of clinicopathological correlation ...
Gameiro,Ana; Gouveia,Miguel; Cardoso,José Carlos; Tellechea,OscarAbstract: Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete clinica...
Fixed drug eruption by etoricoxib confirmed by patch test
Sousa,Aline Soares de; Cardoso,José Carlos; Gouveia,Miguel Pinto; Gameiro,Ana Rita; Teixeira,Vera Barreto; Gonçalo,MariaAbstract: Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, round...
Benign follicular tumors
Tellechea,Oscar; Cardoso,José Carlos; Reis,José Pedro; Ramos,Leonor; Gameiro,Ana Rita; Coutinho,Inês; Baptista,António PoiaresAbstract: Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these l...
Frontal cutaneous meningioma - Case report
Ramos,Leonor; Coutinho,Ines; Cardoso,José Carlos; Garcia,Helena; Cordeiro,Margarida RobaloAbstract Cutaneous meningiomas are rare tumors most commonly located on the scalp. We report the case of a 55-year-old male who presented with a 2x3 cm tumoral lesion on the forehead. The lesion was hard, adherent and covered by normal skin. Incisional biopsy revelead a proliferation of monomorphic round cells, organized in nests and focally forming pseudovascular spaces. Immunohistochemical study revealed posi...