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Nanoscaled hydrated antimony (V) oxide as a new approach to first-line antileis...

Franco, A. M.; Grafova, Iryna A.; Soares, Fabiane Veloso; Gentile, Gennaro; Wyrepkowski, Claudia D C; Bolson, Marcos A.; Sargentini, Ézio

Background: Coordination compounds of pentavalent antimony have been, and remain, the first-line drugs in leishmaniasis treatment for >70 years. Molecular forms of Sb (V) complexes are commercialized as sodium stibogluconate (Pentostam®) and meglumine antimoniate (MA) (Glucantime®). Ever-increasing drug resistance in the parasites limits the use of antimonials, due to the low drug concentrations being administe...

Date: 2020   |   Origin: Oasisbr
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