7 documents found, page 1 of 1
Pathophysiology, Diagnosis and Treatment of Somatosensory Tinnitus: A Scoping R...
Haider, HF; Hoare, DJ; Costa, RF; Potgieter, I; Kikidis, D; Lapira, A; Nikitas, C; Caria, H; Cunha, NT; Paço, JCSomatosensory tinnitus is a generally agreed subtype of tinnitus that is associated with activation of the somatosensory, somatomotor, and visual-motor systems. A key characteristic of somatosensory tinnitus is that is modulated by physical contact or movement. Although it seems common, its pathophysiology, assessment and treatment are not well defined. We present a scoping review on the pathophysiology, diagno...
Biomarkers of Presbycusis and Tinnitus in a Portuguese Older Population
Haider, HF; Flook, M; Aparicio, M; Ribeiro, D; Antunes, M; Szczepek, AJ; Hoare, DJ; Fialho, G; Paço, JC; Caria, HIntroduction: Presbycusis or age-related hearing loss (ARHL) is a ubiquitous health problem. It is estimated that it will affect up to 1.5 billion people by 2025. In addition, tinnitus occurs in a large majority of cases with presbycusis. Glutamate metabotropic receptor 7 (GRM7) and N-acetyltransferase 2 (NAT2) are some of the genetic markers for presbycusis. Objectives: To explore patterns of hearing loss and ...
Rubella in Sub-Saharan Africa and sensorineural hearing loss: a case control study
Caroça, C; Vicente, V; Campelo, P; Chasqueira, M; Caria, H; Silva, S; Paixão, P; Paço, JRubella infection can affect several organs and cause birth defects that are responsible for congenital rubella syndrome (CRS). Congenital hearing loss is the most common symptom of this syndrome, occurring in approximately 60% of CRS cases. Worldwide, over 100 000 babies are born with CRS every year. There is no specific treatment for rubella, but the disease is preventable by vaccination. Since 1969, the rube...
Sickle Cell Trait, Malaria and Sensorineural Hearing Loss–A Case-Control Study ...
Caroça, C; Pereira de Lima, J; Campelo, P; Carolino, E; Caria, H; Paço, J; Nunes-Silva, SBackground: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan Africa. In these countries there is also associated history of anemia and malaria. Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé and Príncipe population. Methods: A retrospective case-control study of a convenience sample was collected du...
DFNB1 locus analysis in São Tomé and Príncipe population
Caroça, C; Morim de Matos, T; Fialho, G; Paço, J; Caria, H
Spectrum and Frequency of GJB2 Mutations in a Cohort of 264 Portuguese Nonsyndr...
Matos, T; Simões-Teixeira, H; Caria, H; Gonçalves, AC; Chora, J; Correia, MC; Moura, C; Rosa, H; Monteiro, L; O'Neill, A; Dias, O; Andrea, M; Fialho, GOBJECTIVE: To assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese nonsyndromic sensorineural hearing loss (NSSHL) patients. DESIGN: Sequencing of the coding region, basal promoter, exon 1, and donor splice site of the GJB2 gene; screening for the presence of the two common GJB6 deletions. STUDY SAMPLE: A cohort of 264 Portuguese NSSHL patients. RESULTS: At least one out of 21 differen...
Aneuploidy induced in lymphocytes of parents of trisomic 21 children
Caria, H; Chaveca, T; Rueff, JA possible predisposition to aneuploidy in trisomic 21 individuals, their parents, and a control group was evaluated. Peripheral blood lymphocytes from those three groups were used to study the induction of micronuclei (MN) by mitomycin C, cyclophosphamide, and quercetin. Induced MN were further analysed by C-banding and CREST antibody. Trisomic 21 individuals have spontaneous frequencies of MN significantly hi...