10 documents found, page 1 of 1

Mpox in People Living with HIV: Clinical Challenges, Preventive Strategies and ...

Monkeypox virus (MPXV) re-emerged in 2022 with a global outbreak that affected more than 100,000 individuals worldwide. People living with HIV (PLWH) accounted for a substantial proportion of cases, raising concerns about disease presentation, management, and outcomes in this population. Evidence indicates that PLWH with advanced or uncontrolled HIV infection experienced more severe mpox, with higher hospitaliz...

The impact of orthopoxvirus vaccination and Mpox infection on cross-protective ...

Background: Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbreak control. We aimed to assess the magnitude, specificity, and durability of cross-reactive immune responses elicited by smallpox vaccines and mpox virus infection. Methods: We did a multicohort observational study involving participants from the USA, B...

Carbapenem-Resistant Enterobacteriaceae Colonization or Infection Was Not Assoc...

Introduction: Carbapenem-resistant Enterobacteriaceae (CRE) epidemiology among liver transplant (LT) recipients is variable. We studied the impact of CRE colonization and infection on LT recipients' outcomes. Methods: This observational cohort study included consecutive adult LT recipients between January 2019 and December 2020 at Curry Cabral Hospital, Lisbon, Portugal. Primary exposures were CRE colonization ...

Viral genetics and transmission dynamics in the second wave of mpox outbreak in...

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...

Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...

Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in...

Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the hi...

Fatal case of progressive Mpox in a patient with AIDS : viral enteropathy and m...

We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccin...

Fatal case of progressive Mpox in a patient with AIDS: viral enteropathy and ma...

We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccin...

Clinical and epidemiological features of hospitalized and ambulatory patients w...

Monkeypox, a neglected and re-emergent zoonotic disease caused by monkeypox virus (MPXV) infection, has been endemic in Central and Western Africa for decades. More recently, an outbreak has spread to a global level, occurring in sites with no previous reported cases and being clustered among men who have sex with men, suggesting new modes of transmission. There is an urgent need for research for a better under...

Estudo Prévio 1 – Arquiteto Subúrbio - Editorial

Por volta dos anos 80, em Portugal, seguindo uma tendência que já era observável em muitas cidades europeias, assistiu-se à mudança de paradigma de atração das cidades, passando da fase centrípeta (onde a cidade atraía as pessoas para o seu centro) para uma fase centrífuga (onde a cidade se expandiu num movimento horizontal e disperso).Desde então, até aos dias de hoje, verifica-se que muitos desses subúrbios c...