3 documents found, page 1 of 1
Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or...
Agua-Doce, Ana; Caridade, Marta; Oliveira, Vanessa G; Bergman, Lisa; Lafaille, Maria C; Lafaille, Juan J; Demengeot, Jocelyne; Graca, LuisIt has been shown that dominant tolerance, namely in transplantation, requires Foxp3+regulatory T cells. Although most tolerance-inducing regimens rely on regulatory T cells, we found that induction of tolerance to proteins in aluminum hydroxide can be achieved in Foxp3-deficient mice using nondepleting anti-CD4 Abs. This type of tolerance is Ag specific, and tolerant mice retain immune competence to respond to...
The fate of CD4+ T cells under tolerance‐inducing stimulation: a modeling persp...
Caridade, Marta; Oliveira, Vanessa; Agua-Doce, Ana; Graca, Luis; Ribeiro, RuyNon-depleting anti-CD4 monoclonal antibodies (MAbs) induce long-term dominant tolerance mediated by regulatory T cells in several animal models of transplantation, allergy and autoimmunity. However, despite many studies on tolerance induction following CD4 blockade, the consequences of this intervention on T-cell kinetics are still unknown. Mathematical models have been useful to understand lymphocyte dynamics,...
Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-b
Monteiro, Marta; Almeida, Catarina F.; Caridade, Marta; Ribot, Julie C.; Duarte, Joana; Agua-Doce, Ana; Wollenberg, Ivonne; Silva-Santos, BrunoInvariant NKT (iNKT) cells were shown to prevent the onset of experimental autoimmune encephalomyelitis in mice following administration of their specific TCR agonist alpha-galactosylceramide. We found that this protection was associated with the emergence of a Foxp3(+) iNKT cell population in cervical lymph nodes. We demonstrate that the differentiation of these cells is critically dependent on TGF-beta in bot...