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Natural Products with Activity against Multidrug-Resistant Tumor Cells
Bernardes de Andrade Carli, Camila [UNESP]; Quilles, Marcela Bassi [UNESP]; Carlos, Iracilda Zeppone [UNESP]Made available in DSpace on 2022-04-29T11:16:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01; Multidrug resistance is the main mechanism by which cancers develop resistance to chemotherapeutic drugs. Consequently, it is also an important factor in the failure of many forms of chemotherapy. This review describes the mechanisms of tumor resistance to drugs and the attempts to discover novel compou...
Immunological and microbiological activity of Davilla elliptica St. Hill. (Dill...
Lopes, Flávia Cristine Mascia [UNESP]; Placeres, Marisa Campos Polesi [UNESP]; Jordão Jr., Cleso Mendonça [UNESP]; Higuchi, Célio Takashi [UNESP]Made available in DSpace on 2022-04-28T20:34:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-01-01; Mycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The immunological activity of Davilla elliptica chloroform extract (DECE) was evaluated in vitro by the determination of hydrogen peroxid...
Probiotic fermented soy product stimulated cytokines in rats on a long-term car...
Benzatti, Fernanda Paulin [UNESP]; Sivieri, Katia [UNESP]; Rossi, Fiizeu Antonio [UNESP]; Carlos, Iracilda Zeppone [UNESP]Made available in DSpace on 2022-04-29T07:12:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-01; Lactic acid bacteria (LAB) when used as probiotics can promote stimulation of immune system through increase of the pathogen phagocytosis and also the cytokines production. The purpose of the present work was to evaluate cytokines production by peritoneal macrophages and splenic lynphocytes in rats with...
Inhibition of nitric oxide and tumour necrosis factor-α production in peritonea...
De Cassia Ribeiro Goncalves, Rita; Kitagawa, Rodrigo Rezende; Raddi, Maria Stella Gonçalves [UNESP]; Carlos, Iracilda Zeppone [UNESP]Made available in DSpace on 2022-04-29T07:13:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-12-01; The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the effects of melanin extracted from the fungus Aspergillus nidulans on the production of the pro-inflammato...
Avaliação preliminar da associação entre anfotericina e hesperina com oxidantes...
Manente, Francine Alessandra [UNESP]; da Silva, Ana Flavia Tostes [UNESP]; Schemberger, Josiane Aparecida [UNESP]; Heinrich, Isabella Aparecida [UNESP]Made available in DSpace on 2022-04-29T07:26:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-01; Amphotericin B (AmB) is drug “gold standard” for the treatment of invasive fungal infections since 1960. However, amphotericin B has high toxicity, which manifests itself most often in the kidneys and in the liver. It is known, since 1985, that self-oxidation of AmB gives different forms of reactive oxi...
Effect of microwave postpolymerization treatment and of storage time in water o...
Jorge, Janaina Habib; Giampaolo, Eunice Teresinha [UNESP]; Vergani, Carlos Eduardo [UNESP]; Pavarina, Ana Cláudia [UNESP]; Machado, Ana Lúcia [UNESP]Made available in DSpace on 2022-04-28T22:37:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-01-01; Objectives: To evaluate the effect of microwave postpolymerization heat treatment and water storage time on the cytotoxicity of denture base and reline acrylic resins. Method and Materials: Sample disks of 6 acrylic resins were fabricated under aseptic conditions (Kooliner, GC; Tokuyama Rebase II, Tokuy...
Foxp3 silencing with antisense oligonucleotide improves immunogenicity of an ad...
Batista-Duharte, Alexander [UNESP]; Sendra, Luis; Herrero, Maria José; Portuondo, Deivys Leandro [UNESP]; Téllez-Martínez, Damiana [UNESP]Made available in DSpace on 2021-06-25T10:56:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Background: In recent years, there has been great interest in developing molecular adjuvants based on antisense oligonucleotides (ASOs) targeting immunosuppressor pathways with inhibitory effects on regulatory T cells (Tregs) to improve immu...
Aqueous extract of Paullinia cupana attenuates renal and hematological effects ...
Bello, Caroline; Prestes, Ana Paula; Schemberger, Josiane Aparecida; Hacke, Ana Carolina Mendes; Pereira, Romaiana PicadaMade available in DSpace on 2021-06-25T22:04:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-03; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); This study aimed to evaluate the effect of aqueous extract of Paullinia cupana (AEG) against ketoprofen side effects, through biochemical, hematological, and histolo...
Transient Foxp3(+) regulatory T-cell depletion enhances protective Th1/Th17 imm...
Batista-Duharte, Alexander [UNESP]; Téllez-Martínez, Damiana [UNESP]; de Andrade, Cleverton Roberto [UNESP]; Polesi, Marisa Campos [UNESP]Made available in DSpace on 2020-12-12T02:20:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01; The role of regulatory T cells (Tregs) on protective immunity in fungal infections, is controversial. Sporotrichosis is an emerging and worldwide-distributed subcutaneous mycosis caused by various related thermodimorphic fungi of the genus Sporothrix. Previously, we showed an elevated percent of Tregs a...
Stability, biological and biopharmaceutical evaluation of the inclusion complex...
Ruz Sanjuan, Vivian [UNESP]; Van den Mooter, Guy; Carlos, Iracilda Zeppone [UNESP]; dos Santos Ramos, Matheus Aparecido [UNESP]Made available in DSpace on 2020-12-12T02:05:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-01; Universidad Nacional de Salta; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The purpose of this work was to evaluate the inclusion complexes (ICs) of 2-(2-nitrovinyl) furan (G-0) with hydroxypropyl and sulfobutylether-β-cyclodextrin intended for drug stabilization. The freeze-dri...