5 documents found, page 1 of 1
Cellulose-based colorimetric test strips for SARS-CoV-2 antibody detection
Sousa, Mariana; Pereira, Ana Cláudia; Correia, Bárbara; Carmo, Anália do; Matos, Ana Miguel; Cruz, Maria Teresa; Moreira, FelisminaThe COVID-19 pandemic highlighted the need for rapid, cost-effective tools to monitor transmission and immune response. We developed two novel paper-based colorimetric biosensors using glutaraldehyde as a protein dyeits first use in this context. Glutaraldehyde reacts with amino groups to generate a brown color, enabling detection of SARS-CoV-2 antibodies. Wathman filter paper was functionalized with (3-aminopr...
Thrombophilic risk factors for retinal vein occlusion
Vieira, Maria J.; Campos, António; Carmo, Anália do; Arruda, Henrique; Martins, Joana; Sousa, João P.The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 67...
Evaluation of markers of outcome in real-world treatment of diabetic macular edema
Campos, António; Campos, Elisa J.; Carmo, Anália do; Caramelo, Francisco; Martins, João; Sousa, João P.; Ambrósio, António; Silva, RufinoObjective: To evaluate short-term markers of outcome in diabetic macular edema (DME). Methods: Prospective interventional case series included 122 eyes of 122 patients with recently diagnosed DME. Eyes were treated with a 3-monthly loading dose of ranibizumab or aflibercept and pro re nata thereafter. Serial enhanced deep imaging SD-OCT high resolution scans were used to measure subfoveal choroidal thickness (S...
Therapeutic implications of an enriched cancer stem-like cell population in a h...
Martins-Neves, Sara R.; Lopes, Áurio; Carmo, Anália do; Paiva, Artur A.; Simões, Paulo C.; Abrunhosa, Antero; Gomes, Célia M. F.Background: Osteosarcoma is a bone-forming tumor of mesenchymal origin that presents a clinical pattern that is consistent with the cancer stem cell model. Cells with stem-like properties (CSCs) have been identified in several tumors and hypothesized as the responsible for the relative resistance to therapy and tumor relapses. In this study, we aimed to identify and characterize CSCs populations in a human oste...
Breakdown of the Inner and Outer Blood Retinal Barrier in Streptozotocin-Induce...
Carmo, Anália do; Ramos, Pedro; Reis, Aldina; Proença, Rui; Cunha-Vaz, J. G.Using vitreous fluorophotometry and quantitative fluorescence microscopy the authors studied the permeability of the blood-retinal barrier (BRB) to fluorescein in control and in 8 days streptozotocin-induced diabetic rats.; http://www.sciencedirect.com/science/article/B6WFD-45JC7TK-T/1/ad834a7e41da87410003af7710548c3d