6 documents found, page 1 of 1
P03-10 Synthetic cannabinoids & neuronal senescence: distinctive responses of i...
Bravo, R. Roque; Carmo, H.; Silva, J.P.; Carvalho, F.; Silva, Diana Dias da; Dias da Silva, Diana CristinaAmong the array of new psychoactive substances, synthetic cannabinoids (SC) stand out as highly popular among consumers. These substances closely resemble, in terms of their pharmacology, Δ9-tetrahydrocannabinol (THC), cannabis’ main active principle, albeit exhibiting full agonism at the cannabinoid receptors 1 and 2. In light of recent scientific findings suggesting that cannabis use can exacerbate ageing-rel...
The synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA accelerate SH-SY5Y pro...
Dias-da-Silva, D.; Roque-Bravo, R.; Silva, J. P.; Carmo, H.; Carvalho, F.Background: Synthetic cannabinoids (SC), one of the most popular groups of new psychoactive substances, display a broad pharmacological action close to that of D9-tetrahydrocannabinol (THC). However, while THC is a partial agonist of the cannabinoid receptors type 1 and 2 (CB1 and CB2, respectively), SC present a full and more potent agonistic activity on these receptors [1]. Since new evidence demonstrates tha...
In vitro neurotoxicity evaluation of piperazine designer drugs in differentiate...
Arbo, M.D.; Silva, R.; Barbosa, D.J.; da Silva, D. Dias; Silva, S.P.; Teixeira, João Paulo; Bastos, M.L.; Carmo, H.Abuse of synthetic drugs is widespread worldwide. Studies indicate that piperazine designer drugs act as substrates at dopaminergic and serotonergic receptors and/or transporters in the brain. This work aimed to investigate the cytotoxicity of N-benzylpiperazine, 1-(3-trifluoromethylphenyl)piperazine, 1-(4-methoxyphenyl)piperazine and 1-(3,4-methylenedioxybenzyl)piperazine in the differentiated human neuroblast...
Mephedrone
Carvalho, F; Carmo, H.; Guedes de Pinho, Paula; Remião, F.; de Lourdes Bastos, M.; Carvalho, Márcia
Influence of the surface coating on the cytotoxicity, genotoxicity and uptake o...
Fraga, S.; Faria, H.; Soares, M.E.; Duarte, J.A.; Soares, L.; Pereira, E.; Costa-Pereira, C.; Teixeira, João Paulo; de Lourdes Bastos, M.; Carmo, H.The toxicological profile of gold nanoparticles (AuNPs) remains controversial. Significant efforts to develop surface coatings to improve biocompatibility have been carried out. In vivo biodistribution studies have shown that the liver is a target for AuNPs accumulation. Therefore, we investigated the effects induced by ~20 nm spherical AuNPs (0-200 μM Au) with two surface coatings, citrate (Cit) compared with ...
Simultaneous determination of amphetamine derivatives in human urine after SPE ...
Soares, M. E.; Carvalho, Márcia; Carmo, H.; Remião, F.; Carvalho, F.; Bastos, M. L.Amphetamine derivatives are a class of compounds increasingly abused as recreational drugs in various regions of the world. Although d-amphetamine (AMPH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are among the most commonly used, the abuse of other designer drugs such as 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and 4-methylthioamphetamine (4-MTA) and their involvement in acute intoxications has be...