3 documents found, page 1 of 1
Valproic acid neuroprotection in the 6-OHDA model of Parkinson’s disease is pos...
Ximenes, José Christian Machado; Neves, Kelly Rose Tavares; Leal, Luzia Kalyne Almeida Moreira; Carmo, Marta Regina Santos doParkinson’s disease is a neurodegenerative disorder where the main hallmark is the dopaminergic neuronal loss. Besides motor symptoms, PDalso causes cognitive decline. Although current therapies focus on the restoration of dopamine levels in the striatum, prevention or disease-modifying therapies are urgently needed. Valproic acid (VA) is a wide spectrum antiepileptic drug, exerting many biochemical and physiol...
Efeito neuroprotetor do antagonismo do receptor P2X7 no Parkinsonismo experimen...
Carmo, Marta Regina Santos doParkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (SN) and a concomitant decrease of dopamine (DA) in the striatum, which can be modeled by 6-OHDA administration. Since ATP released from damaged cells can exert noxious effects on neurons, acting through its P2X7 receptors (P2X7R), the aim of the present study was to investigate the effects of...
Efeito do PPADS, antagonista do receptor P2, sobre a lesão cerebral, comportame...
Carmo, Marta Regina Santos doApós isquemia cerebral, o Trifosfato de Adenosina (ATP) atinge altas concentrações no espaço extracelular e pode atuar como agente tóxico, que causa degeneração celular e morte, mediada através de receptores P2X e P2Y. No presente estudo, foram investigados os efeitos do PPADS, um antagonista não-seletivo dos receptores P2, sobre o comportamento e dano neuronal após isquemia induzida por oclusão permanente da a...