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Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target App...
Hrynchak, Ivanna; Cocioabă, Diana; Fonseca, Alexandra I.; Leonte, Radu; Carmo, Sérgio do; Cornoiu, Roxana; Falcão, Amílcar; Niculae, DanaAntibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cy...
Experimental Determination of Excitation Function Curves through the Measuremen...
Carmo, Sérgio do; Alves, FranciscoThe present work describes a method to determine excitation function curves and, therefore, cross-sections, making use of the irradiation of liquid targets at distinct energies in a biomedical cyclotron. The method relies on the derivative of experimentally measured thick target yield curves to determine the corresponding excitation function curves. The technique is presented as a valid and practical alternativ...
Automated Purification of Radiometals Produced by Liquid Targets
Alves, Vítor H. P.; Carmo, Sérgio do; Alves, Francisco; Abrunhosa, AnteroAn automated process for the production and purification of radiometals produced by irradiating liquid targets in a medical cyclotron, using a commercially available module, has been developed. The method is suitable for the production and purification of radiometals such as 68Ga, 64Cu and 61Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a subst...
A Target-Temperature Monitoring System for Cyclotron Targets: Safety Device and...
Carmo, Sérgio do; Oliveira, Pedro M. de; Alves, FranciscoThe present work describes an experimental system enabling temperature measurement in cyclotron targets’ cooling water during bombardment. The developed system provides sensible and immediate response to variations of irradiation conditions during bombardment and enables quantification of the temperature rise in the cooling water due to beam interaction with the irradiated target and with its collimator. Such a...