2 documents found, page 1 of 1
Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk...
Matos, S; Bernardo, P; Esteves, S; Botelho de Sousa, A; Lemos, M; Ribeiro, P; Silva, M; Nunes, A; Lobato, J; Frade, MJ; Gomes da Silva, M; Chacim, SAlthough mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The objective of this study was to prospectively assess whether extended molecular monitoring using NGS adds clinical value for risk assessment in real-world AML patients...
Intracellular recognition mechanisms. Physiopathologic implications.
Carmo-Fonseca, MThe cell has two distinct organelle systems specialized in the sorting of membranes molecules: the Golgi complex for outward (exocitic) membrane traffic and the endosomal system for inward (endocytic) membrane traffic. Receptor mediated endocytosis allows the cell to internalize specific molecules like LDL, Fe, growth factors and IgA. Within the cell these molecules can follow different pathways, while their re...