3 documents found, page 1 of 1
miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP ...
Barros-Viegas, Ana Teresa; Carmona, Vitor; Ferreiro, Elisabete; Guedes, Joana; Cardoso, Ana Maria S.; Cunha, Pedro; Almeida, Luís Pereira deAlzheimer's disease (AD) is the most common form of dementia worldwide, characterized by progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness and death. Recently, microRNA (miRNA) dysfunction has been associated with increased production and impaired clearance of amyloid-β (Aβ) peptides, whose accumulation is one of the most well-known pathophysiological markers of this dise...
Control of Huntington's Disease-Associated Phenotypes by the Striatum-Enriched ...
Hachigian, Lea J.; Carmona, Vitor; Fenster, Robert J.; Kulicke, Ruth; Heilbut, Adrian; Sittler, Annie; Almeida, Luís Pereira de; Mesirov, Jill P.Alteration of corticostriatal glutamatergic function is an early pathophysiological change associated with Huntington's disease (HD). The factors that regulate the maintenance of corticostriatal glutamatergic synapses post-developmentally are not well understood. Recently, the striatum-enriched transcription factor Foxp2 was implicated in the development of these synapses. Here, we show that, in mice, overexpre...
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph ...
Cunha-Santos, Janete; Duarte-Neves, Joana; Carmona, Vitor; Guarente, Leonard; Almeida, Luís Pereira de; Cavadas, CláudiaMachado-Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression. In this study we find that caloric restriction dramatically rescues the motor incoordination, imbalance and the as...