3 documents found, page 1 of 1
Atherosclerosis and bone loss in humans: results from deceased donors and from ...
Carmona-Fernandes, Diana; Barreira, Sofia; Leonardo, Natacha; Casimiro, Renata I.; Castro, Alice M.; Santos, Pedro Oliveira; Fernandes, António N.Background and Aims: Atherosclerosis and osteoporosis share common risk factors, as well as inflammatory mechanisms. Our aim was to understand how atherosclerotic lesions are related with disturbances in bone. Methods: Gene expression of pro-inflammatory and bone metabolism related proteins (IL-1β, IL-6, IL-17A, TNF, RANKL, OPG, COL1, CTSK, OCL, TRAP, CBFA1, DKK1, SOST, ADIPOQ, and ADIPOR1) were analyzed in art...
Coupling of atherosclerosis progression and bone disturbances in inflammatory r...
Carmona-Fernandes, DianaCardiovascular diseases (CV) and osteoporosis (OP) are among the most prevalent health problems, significantly contributing to increased morbidity and mortality of the population. The incidence of these conditions increases with age and they frequently coexist in the same patient. Epidemiological studies have demonstrated that patients with CV diseases have an increased risk for osteoporotic fractures and that ...
TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthriti...
Canhao, Helena; Rodrigues, Ana Maria; Santos, Maria; Carmona-Fernandes, Diana; Bettencourt, Bruno F.; Cui, Jing; Rocha, Fabiana L.; Canas Silva, JoséBackground: The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. Methods: We evaluated associations between anti-TNF treatment responses assessed b...