46 documents found, page 1 of 5
Comprehensive histopathological analysis of gastric cancer in European and Lati...
Martínez-Ciarpaglini, C; Barros, R; Caballero, C; Boggino, H; Alarcón-Molero, L; Peleteiro, B; Ruiz-García, E; Fernandez-Figueroa, E"Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries. Material a...
Androgen-deprivation therapy and cognitive decline in the NEON-PC prospective s...
Araújo, N; Costa, A; Lopes-Conceição, L; Ferreira, A; Carneiro, F; Oliveira, J; Braga, I; Morais, S; Pacheco-Figueiredo, L; Ruano, L; Cruz, VTBackground: Androgen-deprivation therapy (ADT) has been associated with cognitive decline, but results are conflicting. This study describes changes in cognitive performance in patients with prostate cancer, according to ADT, during the first year after prostate cancer diagnosis. Patients and methods: Patients with prostate cancer treated at the Portuguese Institute of Oncology of Porto (n = 366) were evaluated...
Prevalence of Cognitive Impairment before Prostate Cancer Treatment
Araújo, N; Costa, A; Lopes, C; Lopes-Conceição, L; Ferreira, A; Carneiro, F; Oliveira, J; Morais, S; Pacheco-Figueiredo, L; Ruano, L; Cruz, VTCognitive impairment is common among patients with different types of cancer, even before cancer treatment, but no data were reported among patients with prostate cancer (PCa), who may be at high risk due to advanced age. This study aims to estimate the prevalence of cognitive impairment before PCa treatment. Between February 2018 and April 2021, the NEON-PC cohort recruited 605 patients with PCa proposed for t...
Mechanobiology of Colorectal Cancer
Brás, MM; Sousa, SR; Carneiro, F; Radmacher, M; Granja, PLIn this review, the mechanobiology of colorectal cancer (CRC) are discussed. Mecha-notransduction of CRC is addressed considering the relationship of several biophysical cues and biochemical pathways. Mechanobiology is focused on considering how it may influence epithelial cells in terms of motility, morphometric changes, intravasation, circulation, extravasation, and metastization in CRC development. The roles...
Anxiety and Depression in Patients with Prostate Cancer, at Cancer Diagnosis an...
Duarte, V; Araújo, N; Lopes, C; Costa, A; Ferreira, A; Carneiro, F; Oliveira, J; Braga, I; Morais, S; Pacheco Figueiredo, L; Ruano, L; Tedim Cruz, VTProstate cancer (PCa) is the most prevalent among men, and psychological symptoms may affect many patients. This study aims to describe the prevalence of probable anxiety and depression before PCa treatments and after one year and to identify sociodemographic and clinical factors associated with these outcomes. Between February 2018 and March 2020, 292 patients recently diagnosed with PCa were recruited at the ...
Reviewing Treatment Options for Advanced Renal Cell Carcinoma: Is There Still a...
Fontes-Sousa, M; Magalhães, H; Oliveira, A; Carneiro, F; Palma dos Reis, F; Silvestre Madeira, P; Meireles, SRenal cell carcinoma (RCC) comprises a highly heterogeneous group of kidney tumours built upon distinct genetic- and epigenetic-driven mechanisms and molecular pathways. Therefore, responsiveness to treatment is considerably variable across patients, adding an extra layer of complexity to the already challenging therapeutic decision process. The last decade brought an unprecedented shift in the medical approach...
Cd44v6 high membranous expression is a predictive marker of therapy response in...
Almeida, GM; Pereira, C; Park, JH; Lemos, C; Campelos, S; Gullo, I; Martins, D; Gonçalves, G; Leitão, D; Neto, JL; André, A; Borges, C; Almeida, DIn gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two GC surgical cohorts, from Portugal and South Korea (n = 964), were characterized for the extension of CD44v6 membranous immuno-expression, clinicopathological features, patient...
Histological and mutational profile of diffuse gastric cancer: current knowledg...
Garcia-Pelaez, J; Barbosa-Matos, R; Gullo, I; Carneiro, F; Oliveira, CGastric cancer (GC) pathogenesis is complex and heterogeneous, reflecting morphological, molecular and genetic diversity. Diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC) are the major histological types. GC may be sporadic or hereditary; sporadic GC is related to environmental and genetic low-risk factors and hereditary GC is caused by inherited high-risk mutations, so far identified only for t...
Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease
Pinto-Lopes, P; Melo, F; Afonso, J; Pinto-Lopes, R; Rocha, C; Melo, D; Macedo, G; Dias, CC; Carneiro, F; Magro, FINTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) is a membrane-bound glycoprotein that acts as a receptor but also exists in a soluble form. It has been recognized as a mediator of inflammation and considered a biomarker in inflammatory bowel disease (IBD). METHODS: We evaluated a prospectively recruited cohort, consisting of 101 patients with IBD, using validated clinical indexes; 22 patients with ulcerative colit...
Proteomics analysis of gastric cancer patients with diabetes mellitus
Osorio, H; Silva, C; Ferreira, M; Gullo, I; Máximo, V; Barros, R; Mendonça, F; Oliveira, C; Carneiro, FProteomics is a powerful approach to study the molecular mechanisms of cancer. In this study, we aim to characterize the proteomic profile of gastric cancer (GC) in patients with diabetes mellitus (DM) type 2. Forty GC tissue samples including 19 cases from diabetic patients and 21 cases from individuals without diabetes (control group) were selected for the proteomics analysis. Gastric tissues were processed f...