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Standardization method for measurement of hydroxyurea by Ultra High Efficiency ...

Elias, Darcielle Bruna Dias; Carvalho, Teresa Maria de Jesus Ponte; Soares, Janete Eliza de Sá; Gonçalves, Romélia Pinheiro

Sickle cell anemia (SCA) is a recessively inherited disease characterized by chronic hemolytic anemia, chronic inflammation, and acute episodes of hemolysis. Hydroxyurea (HU) is widely used to increase the levels of fetal hemoglobin (HbF). The objective of this study was to standardize and validate a method for the quantification of HU in human plasma by using ultra high performance liquid chromatography (UPLC)...

Date: 2014   |   Origin: Oasisbr
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