11 documents found, page 1 of 2
The role of N-glycans in regulatory T cells in autoimmunity
Carneiro, P; Vicente, MM; Leite, MI; Santos, ME; Pinho, SS; Fernandes, ÂRegulatory T cells (Tregs) have a key role in the maintenance of immune tolerance and in the prevention of autoimmunity. Recent studies have shown an association between decreased Treg frequency and a deficient suppressive activity with the development of many autoimmune diseases. Although glycosylation, which consists in the addition of glycans to proteins and lipids on the cell surface, is recognized as a cri...
Late Onset Neuromyelitis Optica Spectrum Disorders (LONMOSD) from a Nationwide ...
Santos, E; Moura, J; Samões, R; Sousa, AP; Mendonça, T; Abreu, P; Guimarães, J; Correia, I; Durães, J; Sousa, L; Ferreira, J; de Sá, J; Sousa, FIntroduction: Several neuroimmunological disorders have distinct phenotypes according to the age of onset, as in multiple sclerosis or myasthenia gravis. It is also described that late onset NMOSD (LONMOSD) has a different phenotype. Objective: To describe the clinical/demographic characteristics of the LONMOSD and distinguish them from those with early onset (EONMOSD). Methods: From a nationwide Portuguese NMO...
Neuromyelitis Optica Spectrum Disorders: a Nationwide Portuguese Clinical Epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, AP; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, P; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
Neuromyelitis optica spectrum disorders: A nationwide Portuguese clinical epide...
Santos, E; Rocha, AL; Oliveira, V; Ferro, D; Samões, R; Sousa, AP; Figueiroa, S; Mendonça, T; Abreu, P; Guimarães, J; Sousa, R; Melo, C; Correia, IIntroduction: Neuromyelitis optica spectrum disorder (NMOSD) is a rare disorder in which astrocyte damage and/or demyelination often cause severe neurological deficits. Objective: To identify Portuguese patients with NMOSD and assess their epidemiological/clinical characteristics. Methods: This was a nationwide multicenter study. Twenty-four Portuguese adult and 3 neuropediatric centers following NMOSD patients...
Systemic inflammation as a risk factor for portal vein thrombosis in cirrhosis:...
Nery, F; Carneiro, P; Correia, S; Macedo, C; Gandara, J; Lopes, V; Valadares, D; Ferreira, S; Oliveira, J; Teixeira Gomes, M; Miranda, HP; Rautou, PEBackground and Aims Various risk factors for portal vein thrombosis (PVT) development in patients with cirrhosis have been identified, but the role of systemic inflammatory reaction is unknown. The study aims to assess the association between markers of systemic inflammation and PVT in cirrhosis. Methods Between January 2014 and October 2015, 107 outpatients with cirrhosis and no PVT were recruited, and followe...
Germline cdh1 g212e missense variant: Combining clinical, in vitro and in vivo ...
Figueiredo, J; Mercadillo, F; Melo, S; Barroso, A; Gonçalves, M; Díaz-Tasende, J; Carneiro, P; Robles, L; Colina, F; Ibarrola, C; Perea, JE-cadherin, encoded by CDH1, is an essential molecule for epithelial homeostasis, whose loss or aberrant expression results in disturbed cell–cell adhesion, increased cell invasion and metas-tasis. Carriers of CDH1 germline mutations have a high risk of developing diffuse gastric cancer and lobular breast cancer, associated with the cancer syndrome Hereditary Diffuse Gastric Cancer (HDGC). The ubiquitous availa...
Geographical distribution of e-cadherin germline mutations in the context of di...
Corso, G; Corso, F; Bellerba, F; Carneiro, P; Seixas, S; Cioffi, A; La Vecchia, C; Magnoni, F; Bonanni, B; Veronesi, P; Gandini, S; Figueiredo, JHereditary diffuse gastric cancer (HDGC) is a complex and multifactorial inherited cancer predisposition syndrome caused by CDH1 germline mutations. Nevertheless, current CDH1 genetic screening recommendations disregard an unbalanced worldwide distribution of CDH1 variants, impacting testing efficacy and patient management. In this systematic review, we collected and analyzed all studies describing CDH1 variant...
The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progr...
Moreira, AM; Pereira, J; Melo, S; Fernandes, MS; Carneiro, P; Seruca, R; Figueiredo, JThe extracellular matrix (ECM) is a dynamic and highly organized tissue structure, providing support and maintaining normal epithelial architecture. In the last decade, increasing evidence has emerged demonstrating that alterations in ECM composition and assembly strongly affect cellular function and behavior. Even though the detailed mechanisms underlying cell-ECM crosstalk are yet to unravel, it is well estab...
E-cadherin deregulation in breast cancer
Corso, G; Figueiredo, J; Angelis, SP; Corso, F; Girardi, A; Pereira, J; Seruca, R; Bonanni, B; Carneiro, P; Pravettoni, G; Guerini Rocco, E; Veronesi, PE-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a pro...