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Transcatheter interventions for left-sided valvular heart disease complicated b...
Fraccaro, Chiara; Karam, Nicole; Möllmann, Helge; Bleiziffer, Sabine; Bonaros, Nikolaos; Teles, Rui Campante; Carrilho-Ferreira, Pedro; Chieffo, AlaideValvular heart disease (VHD) is one of the most frequent causes of heart failure (HF) and is associated with poor prognosis, particularly among patients with conservative management. The development and improvement of catheter-based VHD interventions have broadened the indications for transcatheter valve interventions from inoperable/high-risk patients to younger/lower-risk patients. Cardiogenic shock (CS) asso...
Randomized trials fit for the 21st century. A joint opinion from the European S...
Bowman, Louise; Weidinger, Franz; Albert, Michelle A.; Fry, Edward T. A.; Pinto, Fausto J.; Achenbach, Stephan; Bowman, Louise; Casadei, BarbaraRandomized controlled trials are the cornerstone for reliably evaluating therapeutic strategies. However, during the past 25 years, the rules and regulations governing randomized trials and their interpretation have become increasingly burdensome, and the cost and complexity of trials has become prohibitive. The present model is unsustainable, and the development of potentially effective treatments is often sto...
Clinical correlates and prognostic impact of neurologic disorders in Takotsubo ...
Cammann, Victoria L.; Scheitz, Jan F.; von Rennenberg, Regina; Jäncke, Lutz; Nolte, Christian H.; Szawan, Konrad A.; Stengl, Helena; Würdinger, MichaelCardiac alterations are frequently observed after acute neurological disorders. Takotsubo syndrome (TTS) represents an acute heart failure syndrome and is increasingly recognized as part of the spectrum of cardiac complications observed after neurological disorders. A systematic investigation of TTS patients with neurological disorders has not been conducted yet. The aim of the study was to expand insights rega...
Impact of atrial fibrillation on outcome in Takotsubo syndrome: data from the I...
El‐Battrawy, Ibrahim; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; Di Vece, Davide; Rossi, Aurelio; Wischnewsky, Manfred; Hermes‐Laufer, JuliaBackground Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. Methods and Results Patients with TTS were enrolled from the Internati...
Ethnic comparison in takotsubo syndrome : novel insights from the International...
Imori, Yoichi; Kato, Ken; Cammann, Victoria L.; Szawan, Konrad A.; Wischnewsky, Manfred; Dreiding, Sara; Würdinger, Michael; Schönberger, MaximilianBackground: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes. Methods: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enr...
Prognostic impact of acute pulmonary triggers in patients with Takotsubo syndro...
Kato, Ken; Cammann, Victoria L.; Napp, L. Christian; Szawan, Konrad A.; Micek, Jozef; Dreiding, Sara; Levinson, Rena A.; Petkova, VanyaAims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pu...
Coexistence and outcome of coronary artery disease in Takotsubo syndrome
Templin, Christian; Ghadri, Jelena R; Ruschitzka, Frank; Lüscher, Thomas F; Braunwald, Eugene; Bauersachs, Johann; Bax, Jeroen J; Münzel, ThomasAims: Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a l...
Intraventricular thrombus formation and embolism in Takotsubo syndrome
Ding, Katharina J.; Cammann, Victoria L.; Szawan, Konrad A.; Stähli, Barbara E.; Wischnewsky, Manfred; Di Vece, Davide; Citro, RodolfoObjective: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Addit...
Age-related variations in Takotsubo syndrome
Cammann, Victoria L.; Szawan, Konrad A.; Stähli, Barbara E.; Kato, Ken; Budnik, Monika; Wischnewsky, Manfred; Dreiding, Sara; Levinson, Rena A.BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. OBJECTIVES: This study aimed to investigate age-related differences in TTS. METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: #50 years, middle-a...
Clinical predictors and prognostic impact of recovery of wall motion abnormalit...
Jurisic, Stjepan; Gili, Sebastiano; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; D'Ascenzo, Fabrizio; Jaguszewski, Milosz; Bossone, EduardoBackground: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide‐ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut‐off for early LV recovery was determined to be 10 days after t...