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Calciphylaxis: a rare cause of limb ulcer – a case report
Cunha, Roberto; Silva, Manuel; Carneiro, Vítor; Sousa, Pedro; Correia, Mafalda; Vieira, Isabel; Cássio, Isabel; Oliveira, Nelson; Dias, EmanuelBACKGROUND: Calciphylaxis is a rare disease with a poor prognosis predominantly found in end-stage renal disease patients treated with dialysis. This pathology most commonly presents with painful non-healing ulcers, predisposing to high risk of sepsis and death. The authors present a case of bilateral leg ulcers due to calciphylaxis. CASE REPORT: A 40-year-old female patient presented with painful ulcers in bot...
Parametric study of local laser heat treatment technology on multi forming of a...
Pereira, Rui; Peixinho, Nuno; Costa, Sérgio L.; Blanco, Vítor; Carneiro, Vítor; Cortez, SaraThe effectiveness of local laser heat treatment technology to enhance the in situ formability of steels and aluminum alloys has already been widely acknowledged for the one-step forming of components with simple shape geometries. The present study demonstrates that this technology is also able to significantly improve the formability of a complex shaped multi-forming industrial part. An industrial grade advance...
An experimental and numerical study on aluminum alloy tailor heat treated blanks
Pereira, Rui; Peixinho, Nuno; Carneiro, Vítor; Soares, Delfim; Cortez, Sara Isabel Couto; Costa, Sérgio L.; Blanco, VítorInformation is presented on the conceptualization, experimental study, and numerical process simulation of tailor heat treated aluminum alloy blanks. This concept is intended to improve the forming behavior of aluminum parts in challenging conditions. The implementation requires precise control of laser heat treatment parameters within a suitable industrial framework. The study details material properties, heat...
Process and parameters for laser assisted localised heat treatment in manufactu...
Pereira, Rui Pedro; Peixinho, Nuno; Carneiro, Vítor; Cortez, Sara; Costa, Sérgio Luís; Blanco, VítorThis paper presents information and results relevant for the development of a laser heat treatment process suitable to improve manufacturing in high strength steel and high strength aluminium alloys. The challenges with manufacturing of such materials include springback effect and localised fracture. The study details heat cycle and their effect in metallurgical state and mechanical properties. Such laser induc...
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in...
Albergaria, André; Paredes, Joana; Sousa, Bárbara; Milanezi, Maria Fernanda Grillo; Carneiro, Vítor; Bastos, Joana; Costa, Sandra; Vieira, DaniellaThe expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERalpha, both encoding for transcription factors with a potential involvement in the ERalpha-mediated action in breast cancer. The p...