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Glycosaminoglycan distribution in the rat uterine cervix during the estrous cycle

Cubas, Jairo Jose Matozinho; Simões, Ricardo Santos; Oliveira-Filho, Ricardo Martins; Simões, Manuel Jesus; Baracat, Edmund C; Soares-Jr, José Maria

OBJECTIVE: To analyze the amount of glycosaminoglycans in the uterine cervix during each phase of the rat estrous cycle. DESIGN: Based on vaginal smears, forty female, regularly cycling rats were divided into four groups (n = 10 for each group): GI - proestrous, GII - estrous, GIII - metaestrous and GIV - diestrous. Animals were sacrificed at each phase of the cycle, and the cervix was immediately removed and s...

Date: 2010   |   Origin: Oasisbr

Prognostic value of podoplanin expression in intratumoral stroma and neoplastic...

Carvalho, Filomena M; Zaganelli, Fabricia L; Almeida, Bernardo G L; Goes, Joao Carlos Sampaio; Baracat, Edmund C; Carvalho, Jesus P

OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer. MATERIALS AND METHODS: A total of 143 patients with clinical stage I and IIA uterine cervical carcinomas underwent surgery between 2000 and 2007. Clinicopathological data and slides associated with these cases were retrospectively reviewe...

Date: 2010   |   Origin: Oasisbr

Does gestrinone antagonize the effects of estrogen on endometrial implants upon...

Lobo, Vera Lúcia Rodrigues; Soares Júnior, José Maria; Simões, Manuel de Jesus; Simões, Ricardo dos Santos; Lima, Geraldo Rodrigues de

OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscop...

Date: 2008   |   Origin: Oasisbr

Proliferation of the superficial epithelium of ovaries in senile female rats fo...

Perniconi, Sergio Eduardo; Simões, Manuel de Jesus; Simões, Ricardo dos Santos; Haidar, Mauro Abi; Baracat, Edmund C; Soares Jr, Jose Maria

OBJECTIVE: To evaluate the effect of different concentrations of estrogen on the ovarian superficial epithelium in senile female rats. Design: Fifty female rats at 15 months of age and with irregular estrous cycles were selected and randomly divided into five experimental groups containing equal numbers of animals in each: GPROP, control group receiving vehicle only; GE0.05mg, group receiving conjugated equine ...

Date: 2008   |   Origin: Oasisbr


Effects of glucosamine on the tibial epiphyseal disk of ovariectomized rats: mo...

Maganhin, Carla C; Correa, Olga; Regina CT, Gomes; Simões, Ricardo; Baracat, Edmund C; Soares-Jr, José Maria

OBJECTIVE: The aim of this study was to analyze the effect of glucosamine sulfate on the tibial epiphyseal disk of the ovariectomized rats. METHODS: After ovariectomy (OVx), 28 female rats were randomly divided into 4 experimental groups with 7 animals each, treated as follows: OVx 21 - vehicle (NaCl 0.9%) 0.5 mL/day) for 21 days; OVx GS21 - 230 mg/kg/day glucosamine sulphate for 21 days; OVx 45 - treated with ...

Date: 2007   |   Origin: Oasisbr

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