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Schistosoma antigens downregulate CXCL9 production by PBMC of HTLV-1-infected i...
Lima, Luciane Mota; Cardoso, Luciana Santos; Santos, Silvane Braga; Oliveira, Ricardo Riccio; Oliveira, Sérgio Costa; Góes, Alfredo MirandaFundingCNPQ (Universal 479417/2008 3), NIH (R01AI079238A).; Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil; Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnolo...
Clinical and immunological consequences of human T cell leukemia virus type-I a...
Santos, Silvane Braga; Porto, M. Aurélia Fonseca; Muniz, André Luiz; Jesus, Amélia Maria Ribeiro de; Carvalho Filho, Edgar Marcelino deHuman T cell leukemia virus type-I (HTLV-I) infection is associated with spontaneous T cell activation and uncontrolled lymphocyte proliferation. An exacerbated type-1 immune response with production of pro-inflammatory cytokines (interferon-g and tumor necrosis factor-a) is significantly higher in patients with myelopathy associated to HTLV-I than in HTLV-I asymptomatic carriers. In contrast with HTLV-I, a chr...
Effect of TNF-α production inhibitors on the production of pro-inflammatory cyt...
Luna, Tânia; Santos, Silvane Braga; Nascimento, Marcia Cristina Furtado; Porto, M. Aurélia Fonseca; Santos, André Luiz Muniz Alves dosHuman T lymphotropic virus type 1 (HTLV-1) is the causal agent of myelopathy/tropical spastic paraparesis (HAM/TSP), a disease mediated by the immune response. HTLV-1 induces a spontaneous proliferation and production of pro-inflammatory cytokines by T cells, and increasing interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels are potentially involved in tissue damage in diseases related to HTLV-1. Th...
Association of cytokines, neurological disability, and disease duration in HAM/...
Muniz, André Luiz; Rodrigues Junior, Waldyr; Santos, Silvane Braga; Jesus, Amélia Maria Ribeiro de; Porto, M. Aurélia Fonseca; Castro, NévitonOBJECTIVE: To identify clinical and immunological markers associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. RESULTS: 37 pati...